Overview
| Uniprot ID | Q6NVE9 |
|---|
| Protein Name | Protein phosphatase PTC7 homolog |
|---|
| Gene Name | Pptc7 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 248 |
LQELKKLKNSNYESI |
Function
Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:31324765). Positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (By similarity). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (PubMed:37833277, PubMed:38151018). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (PubMed:37833277). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (PubMed:38151018)
Protein Sequence
10
MFSVLSYGRL
20
VARAVLGGLS
30
QTDPRAGGGG
40
GGGGGSSGDY
50
GLVTAGCGFG
60
KDFRKGLLKK
70
GACYGDDACF
80
VARHRSADVL
90
GVADGVGGWR
100
DYGVDPSQFS
110
GTLMRTCERL
120
VKEGRFVPSN
130
PVGILTTSYC
140
ELLQNKVPLL
150
GSSTACIVVL
160
DRSSHRLHTA
170
NLGDSGFLVV
180
RGGEVVHRSD
190
EQQHYFNTPF
200
QLSIAPPEAE
210
GVVLSDSPDA
220
ADSTSFDVQL
230
GDIILTATDG
240
LFDNMPDYMI
250
LQELKKLKNS
260
NYESIQRTAR
270
SIAEQAHELA
280
YDPNYMSPFA
290
QFACDNGLNV
300
RGGKPDDITV
310
LLSIVAEYTD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0000423 |
mitophagy |
| Biological Process |
GO:1901525 |
negative regulation of mitophagy |
| Biological Process |
GO:1904775 |
positive regulation of ubiquinone biosynthetic process |
| Biological Process |
GO:0010795 |
regulation of ubiquinone biosynthetic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.