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Overview

Uniprot IDQ6NW34
Protein NameRibonuclease MRP subunit P64
Gene NameRMP64
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
257 GINKLLNKLFLINEQ
278 ETLLGISKKAKQMKI
279 TLLGISKKAKQMKIN
284 SKKAKQMKINVQNNV
486 SATDTSAKWRLSHCT

Function

Specific component of the MRP ribonucleoprotein endoribonuclease, Rnase/Mrp complex, a ribonucleoprotein complex involved in pre-rRNA processing (PubMed:28115465, PubMed:40413743). May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development (By similarity)

Protein Sequence

10 MMAAVPPGLE 20 PWNRVRIPKA 30 GNRSAVTVQN 40 PGAALDLCIA 50 AVIKECHLVI 60 LSLKSQTLDA 70 ETDVLCAVLY 80 SNHNRMGRHK 90 PHLALKQVEQ 100 CLKRLKNMNL 110 EGSIQDLFEL 120 FSSNENQPLT 130 TKVCVVPSQP 140 VVELVLMKVL 150 GACKLLLRLL 160 DCCCKTFLLT 170 VKHLGLQEFI 180 ILNLVMVGLV 190 SRLWVLYKGV 200 LKRLILLYEP 210 LFGLLQEVAR 220 IQPMPYFKDF 230 TFPSDITEFL 240 GQPYFEAFKK 250 KMPIAFAAKG 260 INKLLNKLFL 270 INEQSPRASE 280 ETLLGISKKA 290 KQMKINVQNN 300 VDLGQPVKNK 310 RVFKEESSEF 320 DVRAFCNQLK 330 HKATQETSFD 340 FKCSQSRLKT 350 TKYSSQKVIG 360 TPHAKSFVQR 370 FREAESFTQL 380 SEEIQMAVVW 390 CRSKKLKAQA 400 IFLGNKLLKS 410 NRLKHLEAQG 420 TSLPKKLECI 430 KTSICNHLLR 440 GSGIKTSKHH 450 LRQRRSQNKF 460 LRRQRKPQRK 470 LQSTLLREIQ 480 QFSQGTRKSA 490 TDTSAKWRLS 500 HCTVHRTDLY 510 PNSKQLLNSG 520 VSMPVIQTKE 530 KMIHENLRGI 540 HENETDSWTV 550 MQINKNSTSG 560 TIKETDDIDD IFALMGV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000172 ribonuclease MRP complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0045665 negative regulation of neuron differentiation
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:0006396 RNA processing
Biological Process GO:0006364 rRNA processing

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.