Search Results
Overview
| Uniprot ID | Q6NXS1 |
|---|---|
| Protein Name | Protein phosphatase inhibitor 2 family member B |
| Gene Name | PPP1R2B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | APDILAKKLAAAEGL |
| 113 | AAEGLEPKYRIQEQE |
| 12 | TASHRPIKGILKNKT |
| 145 | RQFEMRRKLHYNEGL |
| 155 | YNEGLNIKLARQLIS |
| 18 | IKGILKNKTSTTSSM |
Function
Inhibitor of protein-phosphatase 1
Protein Sequence
10
MAASTASHRP
20
IKGILKNKTS
30
TTSSMVASAE
40
QPRRSVDEEL
50
SKKSQKWDEI
60
NILATYHPAD
70
KGYGLMKIDE
80
PSPPYHSMMG
90
DDEDACRDTE
100
TTEAMAPDIL
110
AKKLAAAEGL
120
EPKYRIQEQE
130
SSGEEDSDLS
140
PEEREKKRQF
150
EMRRKLHYNE
160
GLNIKLARQL
170
ISKDLHDDDE
180
DEEMLETADG
190
ESMNTEESNQ
200
GSTPSDQQQN
KLRSS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Biological Process | GO:0005977 | glycogen metabolic process |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0009966 | regulation of signal transduction |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.