Search Results
Overview
| Uniprot ID | Q6NXT2 |
|---|---|
| Protein Name | Histone H3.3C |
| Gene Name | H3-5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | ARKSTGGKAPRKQLA |
| 24 | PRKQLATKAARKSTP |
| 56 | REIRRYQKSTELLIR |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes
Protein Sequence
10
MARTKQTARK
20
STGGKAPRKQ
30
LATKAARKST
40
PSTCGVKPHR
50
YRPGTVALRE
60
IRRYQKSTEL
70
LIRKLPFQRL
80
VREIAQDFNT
90
DLRFQSAAVG
100
ALQEASEAYL
110
VGLLEDTNLC
120
AIHAKRVTIM
130
PKDIQLARRI
RGERA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0051382 | kinetochore assembly |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
Reference
PMID: N/A