Search Results
Overview
| Uniprot ID | Q6NZ67 |
|---|---|
| Protein Name | Mitotic-spindle organizing protein 2B |
| Gene Name | MZT2B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 151 | PKGGGPGKSPTRGST |
Function
Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809)
Protein Sequence
10
MAAQGVGPGP
20
GSAAPPGLEA
30
ARQKLALRRK
40
KVLSTEEMEL
50
YELAQAAGGA
60
IDPDVFKILV
70
DLLKLNVAPL
80
AVFQMLKSMC
90
AGQRLASEPQ
100
DPAAVSLPTS
110
SVPETRGRNK
120
GSAALGGALA
130
LAERSSREGS
140
SQRMPRQPSA
150
TRLPKGGGPG
KSPTRGST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000931 | gamma-tubulin ring complex |
| Cellular Component | GO:0005819 | spindle |
| Biological Process | GO:0007020 | microtubule nucleation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.