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Overview

Uniprot IDQ6NZI2
Protein NameCaveolae-associated protein 1
Gene NameCAVIN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
109 TTSNTVSKLLEKVRK
122 RKVSVNVKTVRGSLE
137 RQAGQIKKLEVNEAE
165 DEVKLPAKLSISKSL
170 PAKLSISKSLKESEA
173 LSISKSLKESEALPE
233 LRRVDDFKKAFSKEK
299 TSRDKLRKSFTPDHV
312 HVVYARSKTAVYKVP

Function

Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity)

Protein Sequence

10 MEDPTLYIVE 20 RPLPGYPDAE 30 APEPSSAGAQ 40 AAEEPSGAGS 50 EELIKSDQVN 60 GVLVLSLLDK 70 IIGAVDQIQL 80 TQAQLEERQA 90 EMEGAVQSIQ 100 GELSKLGKAH 110 ATTSNTVSKL 120 LEKVRKVSVN 130 VKTVRGSLER 140 QAGQIKKLEV 150 NEAELLRRRN 160 FKVMIYQDEV 170 KLPAKLSISK 180 SLKESEALPE 190 KEGEELGEGE 200 RPEEDAAALE 210 LSSDEAVEVE 220 EVIEESRAER 230 IKRSGLRRVD 240 DFKKAFSKEK 250 MEKTKVRTRE 260 NLEKTRLKTK 270 ENLEKTRHTL 280 EKRMNKLGTR 290 LVPAERREKL 300 KTSRDKLRKS 310 FTPDHVVYAR 320 SKTAVYKVPP 330 FTFHVKKIRE 340 GQVEVLKATE 350 MVEVGADDDE 360 GGAERGEAGD 370 LRRGSSPDVH 380 ALLEITEESD 390 AVLVDKSDSD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005901 caveola
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0042134 rRNA primary transcript binding
Biological Process GO:2000147 positive regulation of cell motility
Biological Process GO:0009306 protein secretion
Biological Process GO:0009303 rRNA transcription
Biological Process GO:0006363 termination of RNA polymerase I transcription
Biological Process GO:0006361 transcription initiation at RNA polymerase I promoter

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.