Search Results

Overview

Uniprot ID	Q6NZY4
Protein Name	Zinc finger CCHC domain-containing protein 8
Gene Name	ZCCHC8
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
693	LRIRSLLKNSPRNQQ

Function

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579)

Protein Sequence

10 MAAEVYFGDL 20 ELFEPFDHPE 30 ESIPKPVHTR 40 FKDDDGDEED 50 ENGVGDAELR 60 ERLRQCEETI 70 EQLRAENQEL 80 KRKLNILTRP 90 SGILVNDTKL 100 DGPILQILFM 110 NNAISKQYHQ 120 EIEEFVSNLV 130 KRFEEQQKND 140 VEKTSFNLLP 150 QPSSIVLEED 160 HKVEESCAIK 170 NNKEAFSVVG 180 SVLYFTNFCL 190 DKLGQPLLNE 200 NPQLSEGWEI 210 PKYHQVFSHI 220 VSLEGQEIQV 230 KAKRPKPHCF 240 NCGSEEHQMK 250 DCPMPRNAAR 260 ISEKRKEYMD 270 ACGEANNQNF 280 QQRYHAEEVE 290 ERFGRFKPGV 300 ISEELQDALG 310 VTDKSLPPFI 320 YRMRQLGYPP 330 GWLKEAELEN 340 SGLALYDGKD 350 GTDGETEVGE 360 IQQNKSVTYD 370 LSKLVNYPGF 380 NISTPRGIPD 390 EWRIFGSIPM 400 QACQQKDVFA 410 NYLTSNFQAP 420 GVKSGNKRSS 430 SHSSPGSPKK 440 QKNESNSAGS 450 PADMELDSDM 460 EVPHGSQSSE 470 SFQFQPPLPP 480 DTPPLPRGTP 490 PPVFTPPLPK 500 GTPPLTPSDS 510 PQTRTASGAV 520 DEDALTLEEL 530 EEQQRRIWAA 540 LEQAESVNSD 550 SDVPVDTPLT 560 GNSVASSPCP 570 NELDLPVPEG 580 KTSEKQTLDE 590 PEVPEIFTKK 600 SEAGHASSPD 610 SEVTSLCQKE 620 KAELAPVNTE 630 GALLDNGSVV 640 PNCDISNGGS 650 QKLFPADTSP 660 STATKIHSPI 670 PDMSKFATGI 680 TPFEFENMAE 690 STGMYLRIRS 700 LLKNSPRNQQ KNKKASE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0031499	TRAMP complex
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0180034	co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway
Biological Process	GO:0031124	mRNA 3'-end processing
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0006401	RNA catabolic process
Biological Process	GO:0006396	RNA processing
Biological Process	GO:0016076	snRNA catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.