Search Results
Overview
| Uniprot ID | Q6P1K2 |
|---|---|
| Protein Name | Polyamine-modulated factor 1 |
| Gene Name | PMF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | RPSGIPEKDLHSVMA |
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT
Protein Sequence
10
MAEASSANLG
20
SGCEEKRHEG
30
SSSESVPPGT
40
TISRVKLLDT
50
MVDTFLQKLV
60
AAGSYQRFTD
70
CYKCFYQLQP
80
AMTQQIYDKF
90
IAQLQTSIRE
100
EISDIKEEGN
110
LEAVLNALDK
120
IVEEGKVRKE
130
PAWRPSGIPE
140
KDLHSVMAPY
150
FLQQRDTLRR
160
HVQKQEAENQ
170
QLADAVLAGR
180
RQVEELQLQV
190
QAQQQAWQAL
200
HREQRELVAV
LREPE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0000444 | MIS12/MIND type complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000940 | outer kinetochore |
| Cellular Component | GO:0000922 | spindle pole |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0043522 | leucine zipper domain binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0008608 | attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.