Search Results

Overview

Uniprot IDQ6P1N0
Protein NameCoiled-coil and C2 domain-containing protein 1A
Gene NameCC2D1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
268 QSRQRDYKLAALHAK
480 SGSAPTAKAPPKATS
5 ***MHKRKGPPGPPG
826 QVAGPKGKAPPVPAP

Function

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis

Protein Sequence

10 MHKRKGPPGP 20 PGRGAAAARQ 30 LGLLVDLSPD 40 GLMIPEDGAN 50 DEELEAEFLA 60 LVGGQPPALE 70 KLKGKGPLPM 80 EAIEKMASLC 90 MRDPDEDEEE 100 GTDEDDLEAD 110 DDLLAELNEV 120 LGEEQKASET 130 PPPVAQPKPE 140 APHPGLETTL 150 QERLALYQTA 160 IESARQAGDS 170 AKMRRYDRGL 180 KTLENLLASI 190 RKGNAIDEAD 200 IPPPVAIGKG 210 PASTPTYSPA 220 PTQPAPRIAS 230 APEPRVTLEG 240 PSATAPASSP 250 GLAKPQMPPG 260 PCSPGPLAQL 270 QSRQRDYKLA 280 ALHAKQQGDT 290 TAAARHFRVA 300 KSFDAVLEAL 310 SRGEPVDLSC 320 LPPPPDQLPP 330 DPPSPPSQPP 340 TPATAPSTTE 350 VPPPPRTLLE 360 ALEQRMERYQ 370 VAAAQAKSKG 380 DQRKARMHER 390 IVKQYQDAIR 400 AHKAGRAVDV 410 AELPVPPGFP 420 PIQGLEATKP 430 TQQSLVGVLE 440 TAMKLANQDE 450 GPEDEEDEVP 460 KKQNSPVAPT 470 AQPKAPPSRT 480 PQSGSAPTAK 490 APPKATSTRA 500 QQQLAFLEGR 510 KKQLLQAALR 520 AKQKNDVEGA 530 KMHLRQAKGL 540 EPMLEASRNG 550 LPVDITKVPP 560 APVNKDDFAL 570 VQRPGPGLSQ 580 EAARRYGELT 590 KLIRQQHEMC 600 LNHSNQFTQL 610 GNITETTKFE 620 KLAEDCKRSM 630 DILKQAFVRG 640 LPTPTARFEQ 650 RTFSVIKIFP 660 DLSSNDMLLF 670 IVKGINLPTP 680 PGLSPGDLDV 690 FVRFDFPYPN 700 VEEAQKDKTS 710 VIKNTDSPEF 720 KEQFKLCINR 730 SHRGFRRAIQ 740 TKGIKFEVVH 750 KGGLFKTDRV 760 LGTAQLKLDA 770 LEIACEVREI 780 LEVLDGRRPT 790 GGRLEVMVRI 800 REPLTAQQLE 810 TTTERWLVID 820 PVPAAVPTQV 830 AGPKGKAPPV 840 PAPARESGNR 850 SARPLHSLSV 860 LAFDQERLER 870 KILALRQARR 880 PVPPEVAQQY 890 QDIMQRSQWQ 900 RAQLEQGGVG 910 IRREYAAQLE 920 RQLQFYTEAA 930 RRLGNDGSRD 940 AAKEALYRRN 950 LVESELQRLR R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1905381 negative regulation of snRNA transcription by RNA polymerase II
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0150052 regulation of postsynapse assembly
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.