Search Results
Overview
| Uniprot ID | Q6P1N9 |
|---|---|
| Protein Name | Deoxyribonuclease TATDN1 |
| Gene Name | TATDN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 247 | TAFPTKKKWESGHCL |
| 27 | GIYRGVQKHQDDLQD |
| 46 | AVEIGVKKFMITGGN |
Function
Exhibits 3'-5' exonuclease and apurinic/apyrimidinic (AP) endonuclease activities (in vitro) (PubMed:36881763). Shows preferential AP endonuclease activity on dsDNA substrates and 3'-5' exonuclease activity on ssDNA (PubMed:36881763). Catalyzes decatenation of catenated kinetoplast DNA to produce separated linear DNA in vitro (By similarity). Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity)
Protein Sequence
10
MSRFKFIDIG
20
INLTDPMFRG
30
IYRGVQKHQD
40
DLQDVIGRAV
50
EIGVKKFMIT
60
GGNLQDSKDA
70
LHLAQTNGMF
80
FSTVGCHPTR
90
CGEFEKNNPD
100
LYLKELLNLA
110
ENNKGKVVAI
120
GECGLDFDRL
130
QFCPKDTQLK
140
YFEKQFELSE
150
QTKLPMFLHC
160
RNSHAEFLDI
170
MKRNRDRCVG
180
GVVHSFDGTK
190
EAAAALIDLD
200
LYIGFNGCSL
210
KTEANLEVLK
220
SIPSEKLMIE
230
TDAPWCGVKS
240
THAGSKYIRT
250
AFPTKKKWES
260
GHCLKDRNEP
270
CHIIQILEIM
280
SAVRDEDPLE
290
LANTLYNNTI
KVFFPGI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0008296 | 3'-5'-DNA exonuclease activity |
| Molecular Function | GO:0004520 | DNA endonuclease activity |
| Molecular Function | GO:0046872 | metal ion binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.