Search Results
Overview
| Uniprot ID | Q6P1R4 |
|---|---|
| Protein Name | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like |
| Gene Name | DUS1L |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 370 | GGTEVLSKNKQKKQL |
| 372 | TEVLSKNKQKKQLRN |
| 391 | FDPSLKPKYAKCDQC |
Function
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057, PubMed:39354220). Specifically modifies U16 and U17 in cytoplasmic tRNAs (PubMed:39354220). Affects the level of some mature tRNA and thereby the total cellular translation (PubMed:39354220)
Protein Sequence
10
MPKLQGFEFW
20
SRTLRGARHV
30
VAPMVDQSEL
40
AWRLLSRRHG
50
AQLCYTPMLH
60
AQVFVRDANY
70
RKENLYCEVC
80
PEDRPLIVQF
90
CANDPEVFVQ
100
AALLAQDYCD
110
AIDLNLGCPQ
120
MIAKRGHYGA
130
FLQDEWDLLQ
140
RMILLAHEKL
150
SVPVTCKIRV
160
FPEIDKTVRY
170
AQMLEKAGCQ
180
LLTVHGRTKE
190
QKGPLSGAAS
200
WEHIKAVRKA
210
VAIPVFANGN
220
IQCLQDVERC
230
LRDTGVQGVM
240
SAEGNLHNPA
250
LFEGRSPAVW
260
ELAEEYLDIV
270
REHPCPLSYV
280
RAHLFKLWHH
290
TLQVHQELRE
300
ELAKVKTLEG
310
IAAVSQELKL
320
RCQEEISRQE
330
GAKPTGDLPF
340
HWICQPYIRP
350
GPREGSKEKA
360
GARSKRALEE
370
EEGGTEVLSK
380
NKQKKQLRNP
390
HKTFDPSLKP
400
KYAKCDQCGN
410
PKGNRCVFSL
420
CRGCCKKRAS
430
KETADCPGHG
440
LLFKTKLEKS
450
LAWKEAQPEL
460
QEPQPAAPGT
470
PGGFSEVMGS
ALA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0017150 | tRNA dihydrouridine synthase activity |
| Molecular Function | GO:0102262 | tRNA-dihydrouridine16 synthase activity |
| Molecular Function | GO:0102263 | tRNA-dihydrouridine17 synthase activity |
| Biological Process | GO:0002943 | tRNA dihydrouridine synthesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.