Search Results

Overview

Uniprot IDQ6P2E9
Protein NameEnhancer of mRNA-decapping protein 4
Gene NameEDC4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
907 PAPRLPAKDWKTKGS
926 PKLKRKSKKDDGDAA

Function

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)

Protein Sequence

10 MASCASIDIE 20 DATQHLRDIL 30 KLDRPAGGPS 40 AESPRPSSAY 50 NGDLNGLLVP 60 DPLCSGDSTS 70 ANKTGLRTMP 80 PINLQEKQVI 90 CLSGDDSSTC 100 IGILAKEVEI 110 VASSDSSISS 120 KARGSNKVKI 130 QPVAKYDWEQ 140 KYYYGNLIAV 150 SNSFLAYAIR 160 AANNGSAMVR 170 VISVSTSERT 180 LLKGFTGSVA 190 DLAFAHLNSP 200 QLACLDEAGN 210 LFVWRLALVN 220 GKIQEEILVH 230 IRQPEGTPLN 240 HFRRIIWCPF 250 IPEESEDCCE 260 ESSPTVALLH 270 EDRAEVWDLD 280 MLRSSHSTWP 290 VDVSQIKQGF 300 IVVKGHSTCL 310 SEGALSPDGT 320 VLATASHDGY 330 VKFWQIYIEG 340 QDEPRCLHEW 350 KPHDGRPLSC 360 LLFCDNHKKQ 370 DPDVPFWRFL 380 ITGADQNREL 390 KMWCTVSWTC 400 LQTIRFSPDI 410 FSSVSVPPSL 420 KVCLDLSAEY 430 LILSDVQRKV 440 LYVMELLQNQ 450 EEGHACFSSI 460 SEFLLTHPVL 470 SFGIQVVSRC 480 RLRHTEVLPA 490 EEENDSLGAD 500 GTHGAGAMES 510 AAGVLIKLFC 520 VHTKALQDVQ 530 IRFQPQLNPD 540 VVAPLPTHTA 550 HEDFTFGESR 560 PELGSEGLGS 570 AAHGSQPDLR 580 RIVELPAPAD 590 FLSLSSETKP 600 KLMTPDAFMT 610 PSASLQQITA 620 SPSSSSSGSS 630 SSSSSSSSSL 640 TAVSAMSSTS 650 AVDPSLTRPP 660 EELTLSPKLQ 670 LDGSLTMSSS 680 GSLQASPRGL 690 LPGLLPAPAD 700 KLTPKGPGQV 710 PTATSALSLE 720 LQEVEPLGLP 730 QASPSRTRSP 740 DVISSASTAL 750 SQDIPEIASE 760 ALSRGFGSSA 770 PEGLEPDSMA 780 SAASALHLLS 790 PRPRPGPELG 800 PQLGLDGGPG 810 DGDRHNTPSL 820 LEAALTQEAS 830 TPDSQVWPTA 840 PDITRETCST 850 LAESPRNGLQ 860 EKHKSLAFHR 870 PPYHLLQQRD 880 SQDASAEQSD 890 HDDEVASLAS 900 ASGGFGTKVP 910 APRLPAKDWK 920 TKGSPRTSPK 930 LKRKSKKDDG 940 DAAMGSRLTE 950 HQVAEPPEDW 960 PALIWQQQRE 970 LAELRHSQEE 980 LLQRLCTQLE 990 GLQSTVTGHV 1000 ERALETRHEQ 1010 EQRRLERALA 1020 EGQQRGGQLQ 1030 EQLTQQLSQA 1040 LSSAVAGRLE 1050 RSIRDEIKKT 1060 VPPCVSRSLE 1070 PMAGQLSNSV 1080 ATKLTAVEGS 1090 MKENISKLLK 1100 SKNLTDAIAR 1110 AAADTLQGPM 1120 QAAYREAFQS 1130 VVLPAFEKSC 1140 QAMFQQINDS 1150 FRLGTQEYLQ 1160 QLESHMKSRK 1170 AREQEAREPV 1180 LAQLRGLVST 1190 LQSATEQMAA 1200 TVAGSVRAEV 1210 QHQLHVAVGS 1220 LQESILAQVQ 1230 RIVKGEVSVA 1240 LKEQQAAVTS 1250 SIMQAMRSAA 1260 GTPVPSAHLD 1270 CQAQQAHILQ 1280 LLQQGHLNQA 1290 FQQALTAADL 1300 NLVLYVCETV 1310 DPAQVFGQPP 1320 CPLSQPVLLS 1330 LIQQLASDLG 1340 TRTDLKLSYL 1350 EEAVMHLDHS 1360 DPITRDHMGS 1370 VMAQVRQKLF 1380 QFLQAEPHNS 1390 LGKAARRLSL 1400 MLHGLVTPSL P

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Biological Process GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
Biological Process GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA
Biological Process GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.