Search Results
Overview
| Uniprot ID | Q6P4I2 |
|---|---|
| Protein Name | Integrator complex assembly factor WDR73 |
| Gene Name | WDR73 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 66 | RLSVKENKGLFPERD |
Function
Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489). Associates with INTS9 and INTS11 in the cytoplasm, stabilizing the INTS9-INTS11 heterodimer and blocking the active site of INTS11 (PubMed:39032489). BRAT1 then joins the complex and plugs the active site of INTS11, leading to WDR73 release and nuclear import of INTS9 and INTS11 (PubMed:39032489)
Protein Sequence
10
MDPGDDWLVE
20
SLRLYQDFYA
30
FDLSGATRVL
40
EWIDDKGVFV
50
AGYESLKKNE
60
ILHLKLPLRL
70
SVKENKGLFP
80
ERDFKVRHGG
90
FSDRSIFDLK
100
HVPHTRLLVT
110
SGLPGCYLQV
120
WQVAEDSDVI
130
KAVSTIAVHE
140
KEESLWPRVA
150
VFSTLAPGVL
160
HGARLRSLQV
170
VDLESRKTTY
180
TSDVSDSEEL
190
SSLQVLDADT
200
FAFCCASGRL
210
GLVDTRQKWA
220
PLENRSPGPG
230
SGGERWCAEV
240
GSWGQGPGPS
250
IASLGSDGRL
260
CLLDPRDLCH
270
PVSSVQCPVS
280
VPSPDPELLR
290
VTWAPGLKNC
300
LAISGFDGTV
310
QVYDATSWDG
320
TRSQDGTRSQ
330
VEPLFTHRGH
340
IFLDGNGMDP
350
APLVTTHTWH
360
PCRPRTLLSA
370
TNDASLHVWD
WVDLCAPR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0006997 | nucleus organization |
Reference
PMID: N/A