Search Results

Overview

Uniprot ID	Q6P8J7
Protein Name	Creatine kinase S-type, mitochondrial
Gene Name	Ckmt2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
140	GYDPRVMKHPTDLDA
149	PTDLDASKITHGQFD
209	DLAGRYYKLSEMTEQ
344	SKDPRFSKILENLRL
59	ADYPDLRKHNNCMAE

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity)

Protein Sequence

10 MASAFSKLLT 20 GRNASLLFTT 30 LGTSALTTGY 40 LLNRQKVSAD 50 AREQHKLFPP 60 SADYPDLRKH 70 NNCMAECLTP 80 TIYAKLRNKM 90 TPSGYTLDQC 100 IQTGVDNPGH 110 PFIKTVGMVA 120 GDEESYEVFA 130 DLFDPVIKLR 140 HNGYDPRVMK 150 HPTDLDASKI 160 THGQFDERYV 170 LSSRVRTGRS 180 IRGLSLPPAC 190 SRAERREVEN 200 VAITALEGLK 210 GDLAGRYYKL 220 SEMTEQDQQR 230 LIDDHFLFDK 240 PVSPLLTCAG 250 MARDWPDARG 260 IWHNYDKTFL 270 IWINEEDHTR 280 VISMEKGGNM 290 KRVFERFCRG 300 LKEVERLIQE 310 RGWEFMWNER 320 LGYILTCPSN 330 LGTGLRAGVH 340 VRIPKLSKDP 350 RFSKILENLR 360 LQKRGTGGVD 370 TAAVADVYDI 380 SNIDRIGRSE 390 VELVQIVIDG 400 VNYLVDCEKK 410 LERGQDIKVP PPLPQFGRK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:1901612	cardiolipin binding
Molecular Function	GO:0004111	creatine kinase activity
Biological Process	GO:0046314	phosphocreatine biosynthetic process
Biological Process	GO:0006603	phosphocreatine metabolic process

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.