Search Results

Overview

Uniprot IDQ6PB66
Protein NameLeucine-rich PPR motif-containing protein, mitochondrial
Gene NameLrpprc
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
101 RRTGRITKGLLQRVF
1036 AGEDVTEKTLLSNCK
1048 NCKLKKSKDAYNIFL
1133 LRAALDLKQVPSQIA
1330 MKSYALDKDVASAKA
291 QVRQILEKVEKSDHY
294 QILEKVEKSDHYFMD
669 DLESTLEKLKAEGQP
671 ESTLEKLKAEGQPVG
867 VLCKLVEKGETDLIQ
908 GNYKEAKKIIETPGI

Function

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (By similarity). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (By similarity). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA. Required for maintaining mitochondrial potential (By similarity). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (By similarity)

Protein Sequence

10 MAALLRPARW 20 LLGAAAAPRL 30 PLSLRLPAGV 40 PGRLSSVVRV 50 AAVGSRPAAG 60 ERLSQARLYA 70 IVAEKRDLQE 80 EPAPVRKNSS 90 QFDWALMRLD 100 NSVRRTGRIT 110 KGLLQRVFES 120 TCSSGSPGSN 130 QALLLLRSCG 140 SLLPELSLAE 150 RTEFAHKIWD 160 KLQQLGVVYD 170 VSHYNALLKV 180 YLQNEYKFSP 190 TDFLAKMEGA 200 NIQPNRVTYQ 210 RLIAAYCNVG 220 DIEGASKILG 230 FMKTKDLPIT 240 EAVFSALVTG 250 HARAGDMENA 260 ENILTVMKQA 270 GIEPGPDTYL 280 ALLNAHAERG 290 DIGQVRQILE 300 KVEKSDHYFM 310 DRDFLQVIFS 320 FSKAGYPQYV 330 SEILEKITYE 340 RRSIPDAMNL 350 ILFLATEKLE 360 DTAFQVLLAL 370 PLSKDESSDN 380 FGSFFLRHCV 390 TLDLPPEKLI 400 DYCRRLRDAK 410 LHSSSLQFTL 420 HCALQANRTA 430 LAKAVMEALR 440 EEGFPIRPHY 450 FWPLLAGHQK 460 TKNVQGIIDI 470 LKIMNKVGVD 480 PDQETYINYV 490 FPCFDSAQSV 500 RAALQENECL 510 LASSTFAQAE 520 VKNEAINGNL 530 QNILSFLESN 540 TLPFSFSSLR 550 NSLILGFRRS 560 MNIDLWSKIT 570 ELLYKDERYC 580 SKPPGPAEAV 590 GYFLYNLIDS 600 MSDSEVQAKE 610 ERLRQYFHQL 620 QEMNVKVPEN 630 IYKGICNLLN 640 TYHVPELIKD 650 IKVLVDREKV 660 DSQKTSQVTS 670 SDLESTLEKL 680 KAEGQPVGSA 690 LKQLLLLLCS 700 EENMQKALEV 710 KAKYESDMVI 720 GGYAALINLC 730 CRHDNAEDAW 740 NLKQEVDRLD 750 ASAILDTAKY 760 VALVKVLGKH 770 SRLQDAINIL 780 KEMKEKDVVI 790 KDATVLSFFH 800 ILNGAALRGE 810 IETVKQLHEA 820 IVTLGLAKPS 830 SNISFPLVTV 840 HLEKGDLPAA 850 LEASIACHKK 860 YKVLPRIHDV 870 LCKLVEKGET 880 DLIQKAMDFV 890 SQEQGEMTML 900 YDLFFAFLQT 910 GNYKEAKKII 920 ETPGIRARPT 930 RLQWFCDRCI 940 ASNQVEALEK 950 LVELTEKLFE 960 CDRDQMYYNL 970 LKLYKISSDW 980 QRADAAWTKM 990 QEENIIPRER 1000 TLRLLAEILK 1010 TSNQEVPFDV 1020 PELWFGDDRP 1030 SLSPSSRSAG 1040 EDVTEKTLLS 1050 NCKLKKSKDA 1060 YNIFLKAEKQ 1070 NVVFSSETYS 1080 TLIGLLLSKD 1090 DFTQAMHVKD 1100 FAETHIKGFT 1110 LNDAANSLLI 1120 IRQVRRDYLK 1130 GALATLRAAL 1140 DLKQVPSQIA 1150 VTRLIQALAL 1160 KGDVESIEAI 1170 QRMVAGLDTI 1180 GLSKMVFINN 1190 IALAQMKNNK 1200 LDAAIENIEH 1210 LLASENQAIE 1220 PQYFGLSYLF 1230 RKVIEEQMEP 1240 ALEKLSIMSE 1250 RMANQFALYK 1260 PVTDLFLQLV 1270 DSGKVDEARA 1280 LLERCGAIAE 1290 QSSLLSVFCL 1300 RTSQKPKKAP 1310 VLKTLLELIP 1320 ELRDNDKVYS 1330 CSMKSYALDK 1340 DVASAKALYE 1350 YLTAKNLKLD 1360 DLFLKRYAAL 1370 LKDVGEPVPF 1380 PEPPESFAFY 1390 IKQLKEARES PS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097225 sperm midpiece
Cellular Component GO:0001669 acrosomal vesicle
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0042645 mitochondrial nucleoid
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005637 nuclear inner membrane
Cellular Component GO:0005640 nuclear outer membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0097229 sperm end piece
Molecular Function GO:0048487 beta-tubulin binding
Molecular Function GO:0003730 mRNA 3'-UTR binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003697 single-stranded DNA binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0006914 autophagy
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0097222 mitochondrial mRNA polyadenylation
Biological Process GO:0051028 mRNA transport
Biological Process GO:1905638 negative regulation of mitochondrial mRNA catabolic process
Biological Process GO:0000961 negative regulation of mitochondrial RNA catabolic process
Biological Process GO:0070129 regulation of mitochondrial translation

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.