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Overview

Uniprot IDQ6PCB5
Protein NameLysine-specific demethylase RSBN1L
Gene NameRSBN1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
28 SEKEPFGKLQLSSRD
548 KRTTNEIKNLQYLPR
784 ALNNMDGKNVKAKLD
789 DGKNVKAKLDHVQFA

Function

Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins

Protein Sequence

10 MAEPPSPVHC 20 VAAAAPTATV 30 SEKEPFGKLQ 40 LSSRDPPGSL 50 SAKKVRTEEK 60 KAPRRVNGEG 70 GSGGNSRQLQ 80 PPAAPSPQSY 90 GSPASWSFAP 100 LSAAPSPSSS 110 RSSFSFSAGT 120 AVPSSASASL 130 SQPVPRKLLV 140 PPTLLHAQPH 150 HLLLPAAAAA 160 ASANAKSRRP 170 KEKREKERRR 180 HGLGGAREAG 190 GASREENGEV 200 KPLPRDKIKD 210 KIKERDKEKE 220 REKKKHKVMN 230 EIKKENGEVK 240 ILLKSGKEKP 250 KTNIEDLQIK 260 KVKKKKKKKH 270 KENEKRKRPK 280 MYSKSIQTIC 290 SGLLTDVEDQ 300 AAKGILNDNI 310 KDYVGKNLDT 320 KNYDSKIPEN 330 SEFPFVSLKE 340 PRVQNNLKRL 350 DTLEFKQLIH 360 IEHQPNGGAS 370 VIHAYSNELS 380 HLSPMEMERF 390 AEEFVGLVFS 400 ENENSAAFYV 410 MGIVHGAATY 420 LPDFLDYFSF 430 NFPNSPVKME 440 ILGKKDIETT 450 TMSNFHAQVK 460 RTYSHGTYRA 470 GPMRQISLVG 480 AVDEEVGDYF 490 PEFLDMLEES 500 PFLKCTLPWG 510 TLSSLKLQSR 520 KDSDDGPIMW 530 VRPGEQMIPV 540 ADMPKSPFKR 550 KRTTNEIKNL 560 QYLPRTSEPR 570 EMLFEDRTRA 580 HADHIGQGFE 590 RQTTAAVGVL 600 KAVHCGEWPD 610 QPRITKDVIC 620 FHAEDFLEVV 630 QRMQLDLHEP 640 PLSQCVQWVD 650 DAKLNQLRRE 660 GIRYARIQLY 670 DNDIYFIPRN 680 VVHQFKTVSA 690 VCSLAWHIRL 700 KLYHSEEDTS 710 QNTATHETGT 720 SSDSTSSVLG 730 PHTDNMICAV 740 SKASLDSVFS 750 DKLHSKYELQ 760 QIKHEPIASV 770 RIKEEPVNVN 780 IPEKTTALNN 790 MDGKNVKAKL 800 DHVQFAEFKI 810 DMDSKFENSN 820 KDLKEELCPG 830 NLSLVDTRQH 840 SSAHSNQDKK DDDILC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Molecular Function GO:0051213 dioxygenase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0140457 protein demethylase activity

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.