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Overview

Uniprot ID	Q6PCB7
Protein Name	Long-chain fatty acid transport protein 1
Gene Name	SLC27A1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
598	VDTTGTFKIQKTRLQ

Function

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534, PubMed:20530735, PubMed:21395585, PubMed:28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585)

Protein Sequence

10 MRAPGAGAAS 20 VVSLALLWLL 30 GLPWTWSAAA 40 ALGVYVGSGG 50 WRFLRIVCKT 60 ARRDLFGLSV 70 LIRVRLELRR 80 HQRAGHTIPR 90 IFQAVVQRQP 100 ERLALVDAGT 110 GECWTFAQLD 120 AYSNAVANLF 130 RQLGFAPGDV 140 VAIFLEGRPE 150 FVGLWLGLAK 160 AGMEAALLNV 170 NLRREPLAFC 180 LGTSGAKALI 190 FGGEMVAAVA 200 EVSGHLGKSL 210 IKFCSGDLGP 220 EGILPDTHLL 230 DPLLKEASTA 240 PLAQIPSKGM 250 DDRLFYIYTS 260 GTTGLPKAAI 270 VVHSRYYRMA 280 AFGHHAYRMQ 290 AADVLYDCLP 300 LYHSAGNIIG 310 VGQCLIYGLT 320 VVLRKKFSAS 330 RFWDDCIKYN 340 CTVVQYIGEI 350 CRYLLKQPVR 360 EAERRHRVRL 370 AVGNGLRPAI 380 WEEFTERFGV 390 RQIGEFYGAT 400 ECNCSIANMD 410 GKVGSCGFNS 420 RILPHVYPIR 430 LVKVNEDTME 440 LLRDAQGLCI 450 PCQAGEPGLL 460 VGQINQQDPL 470 RRFDGYVSES 480 ATSKKIAHSV 490 FSKGDSAYLS 500 GDVLVMDELG 510 YMYFRDRSGD 520 TFRWRGENVS 530 TTEVEGVLSR 540 LLGQTDVAVY 550 GVAVPGVEGK 560 AGMAAVADPH 570 SLLDPNAIYQ 580 ELQKVLAPYA 590 RPIFLRLLPQ 600 VDTTGTFKIQ 610 KTRLQREGFD 620 PRQTSDRLFF 630 LDLKQGHYLP 640 LNEAVYTRIC SGAFAL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009925	basal plasma membrane
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0047676	arachidonate-CoA ligase activity
Molecular Function	GO:0015225	biotin transmembrane transporter activity
Molecular Function	GO:0015562	efflux transmembrane transporter activity
Molecular Function	GO:0015245	fatty acid transmembrane transporter activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0005324	long-chain fatty acid transmembrane transporter activity
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity
Molecular Function	GO:0000166	nucleotide binding
Molecular Function	GO:0090434	oleoyl-CoA ligase activity
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity
Molecular Function	GO:0031957	very long-chain fatty acid-CoA ligase activity
Biological Process	GO:1905135	biotin import across plasma membrane
Biological Process	GO:0015878	biotin transport
Biological Process	GO:0140115	export across plasma membrane
Biological Process	GO:0044381	glucose import in response to insulin stimulus
Biological Process	GO:1990379	lipid transport across blood-brain barrier
Biological Process	GO:0015911	long-chain fatty acid import across plasma membrane
Biological Process	GO:0044539	long-chain fatty acid import into cell
Biological Process	GO:0001676	long-chain fatty acid metabolic process
Biological Process	GO:0015909	long-chain fatty acid transport
Biological Process	GO:0001579	medium-chain fatty acid transport
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process
Biological Process	GO:0150104	transport across blood-brain barrier

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.