Overview
| Uniprot ID | Q6PCT2 |
|---|
| Protein Name | F-box/LRR-repeat protein 19 |
|---|
| Gene Name | FBXL19 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 196 |
PPPPPRRKGPLPAGP |
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:24684802, PubMed:29522376). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner (PubMed:23871831). Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration (PubMed:23512198, PubMed:24684802). Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (By similarity). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (By similarity)
Protein Sequence
10
MGMKVPGKGE
20
SGPSALLTPP
30
MSSSSRGPGA
40
GARRRRTRCR
50
RCRACVRTEC
60
GDCHFCRDMK
70
KFGGPGRMKQ
80
SCLLRQCTAP
90
VLPHTAVCLL
100
CGEAGKEDTV
110
EGEEEKFGLS
120
LMECTICNEI
130
VHPGCLKMGK
140
AEGVINAEIP
150
NCWECPRCTQ
160
EGRTSKDSGE
170
GPGRRRADNG
180
EEGASLGSGW
190
KLTEEPPLPP
200
PPPRRKGPLP
210
AGPPPEDVPG
220
PPKRKEREAG
230
NEPPTPRKKV
240
KGGRERHLKK
250
VGGDACLLRG
260
SDPGGPGLLP
270
PRVLNPSQAF
280
SSCHPGLPPE
290
NWEKPKPPLA
300
SAEGPAVPSP
310
SPQREKLERF
320
KRMCQLLERV
330
PDTSSSSSDS
340
DSDSDSSGTS
350
LSEDEAPGEA
360
RNGRRPARGS
370
SGEKENRGGR
380
RAVRPGSGGP
390
LLSWPLGPAP
400
PPRPPQLERH
410
VVRPPPRSPE
420
PDTLPLAAGS
430
DHPLPRAAWL
440
RVFQHLGPRE
450
LCICMRVCRT
460
WSRWCYDKRL
470
WPRMDLSRRK
480
SLTPPMLSGV
490
VRRQPRALDL
500
SWTGVSKKQL
510
MWLLNRLQGL
520
QELVLSGCSW
530
LSVSALGSAP
540
LPALRLLDLR
550
WIEDVKDSQL
560
RELLLPPPDT
570
KPGQTESRGR
580
LQGVAELRLA
590
GLELTDASLR
600
LLLRHAPQLS
610
ALDLSHCAHV
620
GDPSVHLLTA
630
PTSPLRETLV
640
HLNLAGCHRL
650
TDHCLPLFRR
660
CPRLRRLDLR
670
SCRQLSPEAC
680
ARLAAAGPPG
690
PFRCPEEKLL
LKDS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019005 |
SCF ubiquitin ligase complex |
| Molecular Function |
GO:0032452 |
histone demethylase activity |
| Molecular Function |
GO:0003712 |
transcription coregulator activity |
| Molecular Function |
GO:1990756 |
ubiquitin-like ligase-substrate adaptor activity |
| Molecular Function |
GO:0045322 |
unmethylated CpG binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0031146 |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
Reference
PMID: N/A