Search Results
Overview
| Uniprot ID | Q6PF06 |
|---|---|
| Protein Name | tRNA methyltransferase 10 homolog B |
| Gene Name | TRMT10B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | LRALTKDKLLEAKHS |
| 121 | KDKLLEAKHSGPRLC |
| 80 | EKIVAAKKSKRKQEK |
Function
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678)
Protein Sequence
10
MDWKLEGSTQ
20
KVESPVLQGQ
30
EGILEETGED
40
GLPEGFQLLQ
50
IDAEGECQEG
60
EILATGSTAW
70
CSKNVQRKQR
80
HWEKIVAAKK
90
SKRKQEKERR
100
KANRAENPGI
110
CPQHSKRFLR
120
ALTKDKLLEA
130
KHSGPRLCID
140
LSMTHYMSKK
150
ELSRLAGQIR
160
RLYGSNKKAD
170
RPFWICLTGF
180
TTDSPLYEEC
190
VRMNDGFSSY
200
LLDITEEDCF
210
SLFPLETLVY
220
LTPDSEHALE
230
DVDLNKVYIL
240
GGLVDESIQK
250
KVTFQKAREY
260
SVKTARLPIQ
270
EYMVRNQNGK
280
NYHSEILAIN
290
QVFDILSTYL
300
ETHNWPEALK
310
KGVSSGKGYI
LRNSVE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0052905 | tRNA (guanosine(9)-N1)-methyltransferase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0045039 | protein insertion into mitochondrial inner membrane |
| Biological Process | GO:0002939 | tRNA N1-guanine methylation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.