Search Results
Overview
| Uniprot ID | Q6PGP7 |
|---|---|
| Protein Name | Superkiller complex protein 3 |
| Gene Name | SKIC3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 300 | RNLTEGLKESPVCTS |
Function
Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656)
Protein Sequence
10
MSSKEVKTAL
20
KSARDAIRNK
30
EYKEALKHCK
40
TVLKQEKNNY
50
NAWVFIGVAA
60
AELEQPDQAQ
70
SAYKKAAELE
80
PDQLLAWQGL
90
ANLYEKYNHI
100
NAKDDLPGVY
110
QKLLDLYESV
120
DKQKWCDVCK
130
KLVDLYYQEK
140
KHLEVARTWH
150
KLIKTRQEQG
160
AENEELHQLW
170
RKLTQFLAES
180
TEDQNNETQQ
190
LLFTAFENAL
200
GLSDKIPSED
210
HQVLYRHFIQ
220
SLSKFPHESA
230
RLKKACEGMI
240
NIYPTVQYPL
250
EVLCLHLIES
260
GNLTDEGQQY
270
CCRLVEMDSK
280
SGPGLIGLGI
290
KALQDKKYED
300
AVRNLTEGLK
310
ESPVCTSGWY
320
HLAEAQVKMH
330
RPKEAVLSCS
340
QALKIVDNLG
350
ASGNSLYQRN
360
LCLHLKAEAL
370
IKLSDYDSSE
380
EAIRTLDQIS
390
DADNIPGLLV
400
LKSLAYRNKG
410
SFDEAAKIME
420
DLLSSYPDLA
430
EVHALEALIH
440
FTKKDYLQAE
450
KCFQRALEKD
460
TEVAEYHYQL
470
GLTYWFMGEE
480
TRKDKTKALT
490
HFLKAARLDT
500
YMGKVFCYLG
510
HYYRDVVGDK
520
NRARGCYRKA
530
FELDDTDAES
540
GAAAVDLSVE
550
LEDMEMALAI
560
LTTVTQKASA
570
GTAKWAWLRR
580
GLYYLKAGQH
590
SQAVADLQAA
600
LRADPKDFNC
610
WESLGEAYLS
620
RGGYTTALKS
630
FTKASELNPE
640
SIYSVFKVAA
650
IQQILGKYKE
660
AVAQYQMIIK
670
KKEDYVPALK
680
GLGECHLMMA
690
KAALVDYLDG
700
KAVDYIEKAL
710
EYFTCALQHR
720
ADVSCLWKLA
730
GDACTCLYAV
740
APSKVNVHVL
750
GVLLGQKEGK
760
QVLKKNELLH
770
LGGRCYGRAL
780
KLMSTSNTWC
790
DLGINYYRQA
800
QHLAETGSNM
810
NDLKELLEKS
820
LHCLKKAVRL
830
DSNNHLYWNA
840
LGVVACYSGI
850
GNYALAQHCF
860
IKSIQSEQIN
870
AVAWTNLGVL
880
YLTNENIEQA
890
HEAFKMAQSL
900
DPSYLMCWIG
910
QALIAEAVGS
920
YDTMDLFRHT
930
TELNMHTEGA
940
LGYAYWVCTT
950
LQDKSNRETE
960
LYQYNILQMN
970
AIPAAQVILN
980
KYVERIQNYA
990
PAFTMLGYLN
1000
EHLQLKKEAA
1010
NAYQRAILLL
1020
QTAEDQDTYN
1030
VAIRNYGRLL
1040
CSTGEYDKAI
1050
QAFKSTPLEV
1060
LEDIIGFALA
1070
LFMKGLYKES
1080
SKAYERALSI
1090
VESEQDKAHI
1100
LTALAITEYK
1110
QGKTDVAKTL
1120
LFKCSILKEP
1130
TTESLQALCA
1140
LGLAMQDATL
1150
SKAALNELLK
1160
HIKHKDSNYQ
1170
RCLLTSAIYA
1180
LQGRSVAVQK
1190
QISKAVHSNP
1200
GDPALWSLLS
1210
RVVAQYAQRN
1220
AKGGVVAGNV
1230
AHILDSNHGK
1240
KALLYTAVNQ
1250
LAMGSSSAED
1260
EKNTALKTIQ
1270
KAALLSPGDP
1280
AIWAGLMAAC
1290
HADDKLALVN
1300
NTQPKRIDLY
1310
LALLSAVSAS
1320
IKDEKFFENY
1330
NQSLEKWSLS
1340
QAVTGLIDTG
1350
RISEAETLCT
1360
KNLKSNPDQP
1370
AVILLLRQVQ
1380
CKPLLESQKP
1390
LPDAVLEELQ
1400
KTVMSNSTSV
1410
PAWQWLAHVY
1420
QSQGMMRAAE
1430
MCYRKSLQLA
1440
SQRGSWSGKL
1450
SSLLRLALLA
1460
LKVCMANISN
1470
DHWPSLVQEA
1480
TTEALKLCFC
1490
PLAVLLQALL
1500
QFKRKMGARE
1510
TRRLLERVVY
1520
QPGYPKSIAS
1530
TARWYLLRHL
1540
YAKDDYELID
1550
VLVNNAKTHG
1560
DTRALELNQR
LSSQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0055087 | Ski complex |
| Biological Process | GO:0000956 | nuclear-transcribed mRNA catabolic process |
| Biological Process | GO:0070478 | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| Biological Process | GO:0072344 | rescue of stalled cytosolic ribosome |
Reference
PMID: N/A