Search Results

Overview

Uniprot IDQ6PGP7
Protein NameSuperkiller complex protein 3
Gene NameSKIC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
300 RNLTEGLKESPVCTS

Function

Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656)

Protein Sequence

10 MSSKEVKTAL 20 KSARDAIRNK 30 EYKEALKHCK 40 TVLKQEKNNY 50 NAWVFIGVAA 60 AELEQPDQAQ 70 SAYKKAAELE 80 PDQLLAWQGL 90 ANLYEKYNHI 100 NAKDDLPGVY 110 QKLLDLYESV 120 DKQKWCDVCK 130 KLVDLYYQEK 140 KHLEVARTWH 150 KLIKTRQEQG 160 AENEELHQLW 170 RKLTQFLAES 180 TEDQNNETQQ 190 LLFTAFENAL 200 GLSDKIPSED 210 HQVLYRHFIQ 220 SLSKFPHESA 230 RLKKACEGMI 240 NIYPTVQYPL 250 EVLCLHLIES 260 GNLTDEGQQY 270 CCRLVEMDSK 280 SGPGLIGLGI 290 KALQDKKYED 300 AVRNLTEGLK 310 ESPVCTSGWY 320 HLAEAQVKMH 330 RPKEAVLSCS 340 QALKIVDNLG 350 ASGNSLYQRN 360 LCLHLKAEAL 370 IKLSDYDSSE 380 EAIRTLDQIS 390 DADNIPGLLV 400 LKSLAYRNKG 410 SFDEAAKIME 420 DLLSSYPDLA 430 EVHALEALIH 440 FTKKDYLQAE 450 KCFQRALEKD 460 TEVAEYHYQL 470 GLTYWFMGEE 480 TRKDKTKALT 490 HFLKAARLDT 500 YMGKVFCYLG 510 HYYRDVVGDK 520 NRARGCYRKA 530 FELDDTDAES 540 GAAAVDLSVE 550 LEDMEMALAI 560 LTTVTQKASA 570 GTAKWAWLRR 580 GLYYLKAGQH 590 SQAVADLQAA 600 LRADPKDFNC 610 WESLGEAYLS 620 RGGYTTALKS 630 FTKASELNPE 640 SIYSVFKVAA 650 IQQILGKYKE 660 AVAQYQMIIK 670 KKEDYVPALK 680 GLGECHLMMA 690 KAALVDYLDG 700 KAVDYIEKAL 710 EYFTCALQHR 720 ADVSCLWKLA 730 GDACTCLYAV 740 APSKVNVHVL 750 GVLLGQKEGK 760 QVLKKNELLH 770 LGGRCYGRAL 780 KLMSTSNTWC 790 DLGINYYRQA 800 QHLAETGSNM 810 NDLKELLEKS 820 LHCLKKAVRL 830 DSNNHLYWNA 840 LGVVACYSGI 850 GNYALAQHCF 860 IKSIQSEQIN 870 AVAWTNLGVL 880 YLTNENIEQA 890 HEAFKMAQSL 900 DPSYLMCWIG 910 QALIAEAVGS 920 YDTMDLFRHT 930 TELNMHTEGA 940 LGYAYWVCTT 950 LQDKSNRETE 960 LYQYNILQMN 970 AIPAAQVILN 980 KYVERIQNYA 990 PAFTMLGYLN 1000 EHLQLKKEAA 1010 NAYQRAILLL 1020 QTAEDQDTYN 1030 VAIRNYGRLL 1040 CSTGEYDKAI 1050 QAFKSTPLEV 1060 LEDIIGFALA 1070 LFMKGLYKES 1080 SKAYERALSI 1090 VESEQDKAHI 1100 LTALAITEYK 1110 QGKTDVAKTL 1120 LFKCSILKEP 1130 TTESLQALCA 1140 LGLAMQDATL 1150 SKAALNELLK 1160 HIKHKDSNYQ 1170 RCLLTSAIYA 1180 LQGRSVAVQK 1190 QISKAVHSNP 1200 GDPALWSLLS 1210 RVVAQYAQRN 1220 AKGGVVAGNV 1230 AHILDSNHGK 1240 KALLYTAVNQ 1250 LAMGSSSAED 1260 EKNTALKTIQ 1270 KAALLSPGDP 1280 AIWAGLMAAC 1290 HADDKLALVN 1300 NTQPKRIDLY 1310 LALLSAVSAS 1320 IKDEKFFENY 1330 NQSLEKWSLS 1340 QAVTGLIDTG 1350 RISEAETLCT 1360 KNLKSNPDQP 1370 AVILLLRQVQ 1380 CKPLLESQKP 1390 LPDAVLEELQ 1400 KTVMSNSTSV 1410 PAWQWLAHVY 1420 QSQGMMRAAE 1430 MCYRKSLQLA 1440 SQRGSWSGKL 1450 SSLLRLALLA 1460 LKVCMANISN 1470 DHWPSLVQEA 1480 TTEALKLCFC 1490 PLAVLLQALL 1500 QFKRKMGARE 1510 TRRLLERVVY 1520 QPGYPKSIAS 1530 TARWYLLRHL 1540 YAKDDYELID 1550 VLVNNAKTHG 1560 DTRALELNQR LSSQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0055087 Ski complex
Biological Process GO:0000956 nuclear-transcribed mRNA catabolic process
Biological Process GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
Biological Process GO:0072344 rescue of stalled cytosolic ribosome

Reference

PMID: N/A