Overview
| Uniprot ID | Q6PIW4 |
|---|
| Protein Name | Fidgetin-like protein 1 |
|---|
| Gene Name | FIGNL1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 141 |
LASVVIHKEATVFDL |
Function
ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23754376, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity)
Protein Sequence
10
MQTSSSRSVH
20
LSEWQKNYFA
30
ITSGICTGPK
40
ADAYRAQILR
50
IQYAWANSEI
60
SQVCATKLFK
70
KYAEKYSAII
80
DSDNVESGLN
90
NYAENILTLA
100
GSQQTDSDKW
110
QSGLSINNVF
120
KMSSVQKMMQ
130
AGKKFKDSLL
140
EPALASVVIH
150
KEATVFDLPK
160
FSVCGSSQES
170
DSLPNSAHDR
180
DRTQDFPESN
190
RLKLLQNAQP
200
PMVTNTARTC
210
PTFSAPVGES
220
ATAKFHVTPL
230
FGNVKKENHS
240
SAKENIGLNV
250
FLSNQSCFPA
260
ACENPQRKSF
270
YGSGTIDALS
280
NPILNKACSK
290
TEDNGPKEDS
300
SLPTFKTAKE
310
QLWVDQQKKY
320
HQPQRASGSS
330
YGGVKKSLGA
340
SRSRGILGKF
350
VPPIPKQDGG
360
EQNGGMQCKP
370
YGAGPTEPAH
380
PVDERLKNLE
390
PKMIELIMNE
400
IMDHGPPVNW
410
EDIAGVEFAK
420
ATIKEIVVWP
430
MLRPDIFTGL
440
RGPPKGILLF
450
GPPGTGKTLI
460
GKCIASQSGA
470
TFFSISASSL
480
TSKWVGEGEK
490
MVRALFAVAR
500
CQQPAVIFID
510
EIDSLLSQRG
520
DGEHESSRRI
530
KTEFLVQLDG
540
ATTSSEDRIL
550
VVGATNRPQE
560
IDEAARRRLV
570
KRLYIPLPEA
580
SARKQIVINL
590
MSKEQCCLSE
600
EEIEQIVQQS
610
DAFSGADMTQ
620
LCREASLGPI
630
RSLQTADIAT
640
ITPDQVRPIA
650
YIDFENAFRT
660
VRPSVSPKDL
670
ELYENWNKTF
GCGK
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0010569 |
regulation of double-strand break repair via homologous recombination |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0000228 |
nuclear chromosome |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0016787 |
hydrolase activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0008568 |
microtubule severing ATPase activity |
| Biological Process |
GO:0046034 |
ATP metabolic process |
| Biological Process |
GO:0071479 |
cellular response to ionizing radiation |
| Biological Process |
GO:0035825 |
homologous recombination |
| Biological Process |
GO:0036297 |
interstrand cross-link repair |
| Biological Process |
GO:0007140 |
male meiotic nuclear division |
| Biological Process |
GO:0051013 |
microtubule severing |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0001649 |
osteoblast differentiation |
| Biological Process |
GO:0033687 |
osteoblast proliferation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.