Search Results

Overview

Uniprot IDQ6PL18
Protein NameATPase family AAA domain-containing protein 2
Gene NameATAD2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1169 LKRKIRKKSNWYLGT
300 RYYLRQRKATVYYQA
47 RSAGAAQKKPAATTA

Function

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells

Protein Sequence

10 MVVLRSSLEL 20 HNHSAASATG 30 SLDLSSDFLS 40 LEHIGRRRLR 50 SAGAAQKKPA 60 ATTAKAGDGS 70 SVKEVETYHR 80 TRALRSLRKD 90 AQNSSDSSFE 100 KNVEITEQLA 110 NGRHFTRQLA 120 RQQADKKKEE 130 HREDKVIPVT 140 RSLRARNIVQ 150 STEHLHEDNG 160 DVEVRRSCRI 170 RSRYSGVNQS 180 MLFDKLITNT 190 AEAVLQKMDD 200 MKKMRRQRMR 210 ELEDLGVFNE 220 TEESNLNMYT 230 RGKQKDIQRT 240 DEETTDNQEG 250 SVESSEEGED 260 QEHEDDGEDE 270 DDEDDDDDDD 280 DDDDDDDEDD 290 EDEEDGEEEN 300 QKRYYLRQRK 310 ATVYYQAPLE 320 KPRHQRKPNI 330 FYSGPASPAR 340 PRYRLSSAGP 350 RSPYCKRMNR 360 RRHAIHSSDS 370 TSSSSSEDEQ 380 HFERRRKRSR 390 NRAINRCLPL 400 NFRKDELKGI 410 YKDRMKIGAS 420 LADVDPMQLD 430 SSVRFDSVGG 440 LSNHIAALKE 450 MVVFPLLYPE 460 VFEKFKIQPP 470 RGCLFYGPPG 480 TGKTLVARAL 490 ANECSQGDKR 500 VAFFMRKGAD 510 CLSKWVGESE 520 RQLRLLFDQA 530 YQMRPSIIFF 540 DEIDGLAPVR 550 SSRQDQIHSS 560 IVSTLLALMD 570 GLDSRGEIVV 580 IGATNRLDSI 590 DPALRRPGRF 600 DREFLFSLPD 610 KEARKEILKI 620 HTRDWNPKPL 630 DTFLEELAEN 640 CVGYCGADIK 650 SICAEAALCA 660 LRRRYPQIYT 670 TSEKLQLDLS 680 SINISAKDFE 690 VAMQKMIPAS 700 QRAVTSPGQA 710 LSTVVKPLLQ 720 NTVDKILEAL 730 QRVFPHAEFR 740 TNKTLDSDIS 750 CPLLESDLAY 760 SDDDVPSVYE 770 NGLSQKSSHK 780 AKDNFNFLHL 790 NRNACYQPMS 800 FRPRILIVGE 810 PGFGQGSHLA 820 PAVIHALEKF 830 TVYTLDIPVL 840 FGVSTTSPEE 850 TCAQVIREAK 860 RTAPSIVYVP 870 HIHVWWEIVG 880 PTLKATFTTL 890 LQNIPSFAPV 900 LLLATSDKPH 910 SALPEEVQEL 920 FIRDYGEIFN 930 VQLPDKEERT 940 KFFEDLILKQ 950 AAKPPISKKK 960 AVLQALEVLP 970 VAPPPEPRSL 980 TAEEVKRLEE 990 QEEDTFRELR 1000 IFLRNVTHRL 1010 AIDKRFRVFT 1020 KPVDPDEVPD 1030 YVTVIKQPMD 1040 LSSVISKIDL 1050 HKYLTVKDYL 1060 RDIDLICSNA 1070 LEYNPDRDPG 1080 DRLIRHRACA 1090 LRDTAYAIIK 1100 EELDEDFEQL 1110 CEEIQESRKK 1120 RGCSSSKYAP 1130 SYYHVMPKQN 1140 STLVGDKRSD 1150 PEQNEKLKTP 1160 STPVACSTPA 1170 QLKRKIRKKS 1180 NWYLGTIKKR 1190 RKISQAKDDS 1200 QNAIDHKIES 1210 DTEETQDTSV 1220 DHNETGNTGE 1230 SSVEENEKQQ 1240 NASESKLELR 1250 NNSNTCNIEN 1260 ELEDSRKTTA 1270 CTELRDKIAC 1280 NGDASSSQII 1290 HISDENEGKE 1300 MCVLRMTRAR 1310 RSQVEQQQLI 1320 TVEKALAILS 1330 QPTPSLVVDH 1340 ERLKNLLKTV 1350 VKKSQNYNIF 1360 QLENLYAVIS 1370 QCIYRHRKDH 1380 DKTSLIQKME 1390 QEVENFSCSR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042393 histone binding
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0006337 nucleosome disassembly
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045815 transcription initiation-coupled chromatin remodeling

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.