Search Results
Overview
| Uniprot ID | Q6PUV4 |
|---|---|
| Protein Name | Complexin-2 |
| Gene Name | CPLX2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | QALGGATKDMGKMLG |
Function
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044305 | calyx of Held |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0043303 | mast cell degranulation |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0017157 | regulation of exocytosis |
| Biological Process | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0006904 | vesicle docking involved in exocytosis |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex |
| Cellular Component | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.