Search Results
Overview
| Uniprot ID | Q6Q2J0 |
|---|---|
| Protein Name | Amine oxidase [flavin-containing] A |
| Gene Name | MAOA |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | LVQYVKGKSYPFRGA |
| 218 | TNGGQERKFVGGSGQ |
| 372 | HKEVRKRKICELYAK |
| 465 | EILNALGKVSKKDIW |
| 82 | NRILRLSKELGLETY |
Function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline
Protein Sequence
10
MERQEKANNA
20
GHMVDVVVIG
30
GGISGLSAAK
40
LLNEYGINVL
50
VLEARDRVGG
60
RTYTVRNENV
70
DYVDVGGAYV
80
GPTQNRILRL
90
SKELGLETYK
100
VNVNECLVQY
110
VKGKSYPFRG
120
AFPPVWNPIA
130
YLDYNNLWRT
140
MDDMGKKIPA
150
DAPWESPHAE
160
EWDKMTMKDL
170
IDKICWTKTA
180
KRFASLFVNI
190
NVTSEPHEVS
200
ALWFLWYVKQ
210
CGGTTRIFSV
220
TNGGQERKFV
230
GGSGQVSERI
240
MHLLGDRVKL
250
RCPVTYVDQS
260
GDNIIVETLN
270
HELYECQYVI
280
SAIPPTLTAK
290
IHFRPELPSE
300
RNQLIQRLPM
310
GAIIKCMMYY
320
KEAFWKKKNY
330
CGCMIIEDEE
340
APISITLDDT
350
KPDGSLPAIM
360
GFILARKADR
370
LAKVHKEVRK
380
RKICELYAKV
390
LGSQEASHPV
400
HYEEKNWCEE
410
QYSGGCYTAY
420
FPPGIMTQYG
430
RVIRQPVGRI
440
FFAGTETATQ
450
WSGYMEGAVE
460
AGERAAREIL
470
NALGKVSKKD
480
IWLREPESED
490
VPAFEITRTF
500
WERNLPSVTG
510
LLKIIGFSTS
520
VTALWLAVYK
FRLLTRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0097621 | monoamine oxidase activity |
| Molecular Function | GO:0008131 | primary methylamine oxidase activity |
| Biological Process | GO:0006584 | catecholamine metabolic process |
| Biological Process | GO:0019607 | phenylethylamine catabolic process |
| Biological Process | GO:0042428 | serotonin metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.