Overview
| Uniprot ID | Q6QAQ1 |
|---|
| Protein Name | Actin, cytoplasmic 1 |
|---|
| Gene Name | ACTB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 113 |
TEAPLNPKANREKMT |
| 291 |
KCDVDIRKDLYANTV |
Function
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (By similarity). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160)
Protein Sequence
10
MDDDIAALVV
20
DNGSGMCKAG
30
FAGDDAPRAV
40
FPSIVGRPRH
50
QGVMVGMGQK
60
DSYVGDEAQS
70
KRGILTLKYP
80
IEHGIVTNWD
90
DMEKIWHHTF
100
YNELRVAPEE
110
HPVLLTEAPL
120
NPKANREKMT
130
QIMFETFNTP
140
AMYVAIQAVL
150
SLYASGRTTG
160
IVMDSGDGVT
170
HTVPIYEGYA
180
LPHAILRLDL
190
AGRDLTDYLM
200
KILTERGYSF
210
TTTAEREIVR
220
DIKEKLCYVA
230
LDFEQEMATA
240
ASSSSLEKSY
250
ELPDGQVITI
260
GNERFRCPEA
270
LFQPSFLGME
280
SCGIHETTFN
290
SIMKCDVDIR
300
KDLYANTVLS
310
GGTTMYPGIA
320
DRMQKEITAL
330
APSTMKIKII
340
APPERKYSVW
350
IGGSILASLS
360
TFQQMWISKQ
370
EYDESGPSIV
HRKCF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005884 |
actin filament |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0043296 |
apical junction complex |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005903 |
brush border |
| Cellular Component |
GO:0044305 |
calyx of Held |
| Cellular Component |
GO:0030863 |
cortical cytoskeleton |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0097433 |
dense body |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0035267 |
NuA4 histone acetyltransferase complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098871 |
postsynaptic actin cytoskeleton |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
| Cellular Component |
GO:0045202 |
synapse |
| Cellular Component |
GO:0070160 |
tight junction |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0019894 |
kinesin binding |
| Molecular Function |
GO:0050998 |
nitric-oxide synthase binding |
| Molecular Function |
GO:0030235 |
nitric-oxide synthase regulator activity |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0098973 |
structural constituent of postsynaptic actin cytoskeleton |
| Molecular Function |
GO:0030957 |
Tat protein binding |
| Molecular Function |
GO:0141108 |
transporter regulator activity |
| Biological Process |
GO:0034333 |
adherens junction assembly |
| Biological Process |
GO:0045176 |
apical protein localization |
| Biological Process |
GO:0007409 |
axonogenesis |
| Biological Process |
GO:0048870 |
cell motility |
| Biological Process |
GO:0072749 |
cellular response to cytochalasin B |
| Biological Process |
GO:0007163 |
establishment or maintenance of cell polarity |
| Biological Process |
GO:0007017 |
microtubule-based process |
| Biological Process |
GO:0001738 |
morphogenesis of a polarized epithelium |
| Biological Process |
GO:1905168 |
positive regulation of double-strand break repair via homologous recombination |
| Biological Process |
GO:0071896 |
protein localization to adherens junction |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0051621 |
regulation of norepinephrine uptake |
| Biological Process |
GO:1903076 |
regulation of protein localization to plasma membrane |
| Biological Process |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
| Biological Process |
GO:0150111 |
regulation of transepithelial transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.