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Overview

Uniprot IDQ6QNK2
Protein NameAdhesion G protein-coupled receptor D1
Gene NameADGRD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
326 NLTKTFLKAVGEILL

Function

Adhesion G protein-coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271)

Protein Sequence

10 MEKLLRLCCW 20 YSWLLLFYYN 30 FQVRGVYSRS 40 QDHPGFQVLA 50 SASHYWPLEN 60 VDGIHELQDT 70 TGDIVEGKVN 80 KGIYLKEEKG 90 VTLLYYGRYN 100 SSCISKPEQC 110 GPEGVTFSFF 120 WKTQGEQSRP 130 IPSAYGGQVI 140 SNGFKVCSSG 150 GRGSVELYTR 160 DNSMTWEASF 170 SPPGPYWTHV 180 LFTWKSKEGL 190 KVYVNGTLST 200 SDPSGKVSRD 210 YGESNVNLVI 220 GSEQDQAKCY 230 ENGAFDEFII 240 WERALTPDEI 250 AMYFTAAIGK 260 HALLSSTLPS 270 LFMTSTASPV 280 MPTDAYHPII 290 TNLTEERKTF 300 QSPGVILSYL 310 QNVSLSLPSK 320 SLSEQTALNL 330 TKTFLKAVGE 340 ILLLPGWIAL 350 SEDSAVVLSL 360 IDTIDTVMGH 370 VSSNLHGSTP 380 QVTVEGSSAM 390 AEFSVAKILP 400 KTVNSSHYRF 410 PAHGQSFIQI 420 PHEAFHRHAW 430 STVVGLLYHS 440 MHYYLNNIWP 450 AHTKIAEAMH 460 HQDCLLFATS 470 HLISLEVSPP 480 PTLSQNLSGS 490 PLITVHLKHR 500 LTRKQHSEAT 510 NSSNRVFVYC 520 AFLDFSSGEG 530 VWSNHGCALT 540 RGNLTYSVCR 550 CTHLTNFAIL 560 MQVVPLELAR 570 GHQVALSSIS 580 YVGCSLSVLC 590 LVATLVTFAV 600 LSSVSTIRNQ 610 RYHIHANLSF 620 AVLVAQVLLL 630 ISFRLEPGTT 640 PCQVMAVLLH 650 YFFLSAFAWM 660 LVEGLHLYSM 670 VIKVFGSEDS 680 KHRYYYGMGW 690 GFPLLICIIS 700 LSFAMDSYGT 710 SNNCWLSLAS 720 GAIWAFVAPA 730 LFVIVVNIGI 740 LIAVTRVISQ 750 ISADNYKIHG 760 DPSAFKLTAK 770 AVAVLLPILG 780 TSWVFGVLAV 790 NGCAVVFQYM 800 FATLNSLQGL 810 FIFLFHCLLN 820 SEVRAAFKHK 830 TKVWSLTSSS 840 ARTSNAKPFH 850 SDLMNGTRPG 860 MASTKLSPWD 870 KSSHSAHRVD LSAV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004930 G protein-coupled receptor activity
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0014819 regulation of skeletal muscle contraction

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.