Search Results

Overview

Uniprot ID	Q6RFH5
Protein Name	WD repeat-containing protein 74
Gene Name	WDR74
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
359	LEAAAKRKLSGLEQP

Function

Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity)

Protein Sequence

10 MAAAAARWNH 20 VWVGTETGIL 30 KGVNLQRKQA 40 ANFTAGGQPR 50 REEAVSALCW 60 GTGGETQMLV 70 GCADRTVKHF 80 STEDGIFQGQ 90 RHCPGGEGMF 100 RGLAQADGTL 110 ITCVDSGILR 120 VWHDKDKDTS 130 SDPLLELRVG 140 PGVCRMRQDP 150 AHPHVVATGG 160 KENALKIWDL 170 QGSEEPVFRA 180 KNVRNDWLDL 190 RVPIWDQDIQ 200 FLPGSQKLVT 210 CTGYHQVRVY 220 DPASPQRRPV 230 LETTYGEYPL 240 TAMTLTPGGN 250 SVIVGNTHGQ 260 LAEIDLRQGR 270 LLGCLKGLAG 280 SVRGLQCHPS 290 KPLLASCGLD 300 RVLRIHRIQN 310 PRGLEHKVYL 320 KSQLNCLLLS 330 GRDNWEDEPQ 340 EPQEPNKVPL 350 EDTETDELWA 360 SLEAAAKRKL 370 SGLEQPQGAL 380 QTRRRKKKRP GSTSP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0030687	preribosome, large subunit precursor
Biological Process	GO:0001825	blastocyst formation
Biological Process	GO:0042273	ribosomal large subunit biogenesis
Biological Process	GO:0016070	RNA metabolic process
Biological Process	GO:0006364	rRNA processing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.