Overview
| Uniprot ID | Q6RVA9 |
|---|
| Protein Name | Caveolin-1 |
|---|
| Gene Name | CAV1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 5 |
***MSGGKYVDSEGH |
| 57 |
DLVNRDPKHLNDDVV |
Function
May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)
Protein Sequence
10
MSGGKYVDSE
20
GHLYTVPIRE
30
QGNIYKPNNK
40
AMAEEMNEKQ
50
VYDAHTKEID
60
LVNRDPKHLN
70
DDVVKIDFED
80
VIAEPEGTHS
90
FDGIWKASFT
100
TFTVTKYWFY
110
RLLSALFGIP
120
MALIWGIYFA
130
ILSFLHIWAV
140
VPCIKSFLIE
150
IQCISRVYSI
160
YVHTFCDPLF
170
EAIGKIFSNI
RINMQKEI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005901 |
caveola |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Molecular Function |
GO:0008142 |
oxysterol binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0044325 |
transmembrane transporter binding |
| Biological Process |
GO:0070836 |
caveola assembly |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0001937 |
negative regulation of endothelial cell proliferation |
| Biological Process |
GO:0031623 |
receptor internalization |
| Biological Process |
GO:0051480 |
regulation of cytosolic calcium ion concentration |
| Biological Process |
GO:0031295 |
T cell costimulation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.