Search Results
Overview
| Uniprot ID | Q6SA08 |
|---|---|
| Protein Name | Testis-specific serine/threonine-protein kinase 4 |
| Gene Name | TSSK4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 319 | CQLHNTTKQHQSLQI |
Function
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity)
Protein Sequence
10
MGKGDVLEAA
20
PTTTAYHSLM
30
DEYGYEVGKA
40
IGHGSYGSVY
50
EAFYTKQKVM
60
VAVKIISKKK
70
ASDDYLNKFL
80
PREIQVMKVL
90
RHKYLINFYR
100
AIESTSRVYI
110
ILELAQGGDV
120
LEWIQRYGAC
130
SEPLAGKWFS
140
QLTLGIAYLH
150
SKSIVHRDLK
160
LENLLLDKWE
170
NVKISDFGFA
180
KMVPSNQPVG
190
CSPSYRQVNC
200
FSHLSQTYCG
210
SFAYACPEIL
220
RGLPYNPFLS
230
DTWSMGVILY
240
TLVVAHLPFD
250
DTNLKKLLRE
260
TQKEVTFPAN
270
HTISQECKNL
280
ILQMLRQATK
290
RATILDIIKD
300
SWVLKFQPEQ
310
PTHEIRLLEA
320
MCQLHNTTKQ
HQSLQITT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0009566 | fertilization |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0007286 | spermatid development |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.