Search Results
Overview
| Uniprot ID | Q6SEG5 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| Gene Name | UCHL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | QFLSETEKLSPEDRA |
| 135 | DRAKCFEKNEAIQAA |
| 199 | SLLQDAAKVCREFTE |
| 221 | FSAVALCKAA***** |
| 65 | QHENFRKKQIEELKG |
| 71 | KKQIEELKGQEVSPK |
| 78 | KGQEVSPKVYFMKQT |
Function
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity)
Protein Sequence
10
MQLKPMEINP
20
EMLNKVLTRL
30
GVAGHWRFAD
40
VLGLEEESLG
50
SVPAPACALL
60
LLFPLTAQHE
70
NFRKKQIEEL
80
KGQEVSPKVY
90
FMKQTIGNSC
100
GTIGLIHAVA
110
NNQDKLEFED
120
GSVLKQFLSE
130
TEKLSPEDRA
140
KCFEKNEAIQ
150
AAHDAVAQEG
160
QCRVDDKVNF
170
HFILFNNVDG
180
HLYELDGRMP
190
FPVNHGASSE
200
DSLLQDAAKV
210
CREFTEREQG
220
EVRFSAVALC
KAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0031694 | alpha-2A adrenergic receptor binding |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0008242 | omega peptidase activity |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0030547 | signaling receptor inhibitor activity |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0045821 | positive regulation of glycolytic process |
| Biological Process | GO:0030163 | protein catabolic process |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.