Search Results
Overview
| Uniprot ID | Q6SPF0 |
|---|---|
| Protein Name | Sterile alpha motif domain-containing protein 1 |
| Gene Name | SAMD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 88 | AVLRVSYKGSISYRN |
Function
Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929)
Protein Sequence
10
MAGPPALPPP
20
ETAAAATTAA
30
AASSSAASPH
40
YQEWILDTID
50
SLRSRKARPD
60
LERICRMVRR
70
RHGPEPERTR
80
AELEKLIQQR
90
AVLRVSYKGS
100
ISYRNAARVQ
110
PPRRGATPPA
120
PPRAPRGAPA
130
AAAAAAPPPT
140
PAPPPPPAPV
150
AAAAPARAPR
160
AAAAAATAPP
170
SPGPAQPGPR
180
AQRAAPLAAP
190
PPAPAAPPAV
200
APPAGPRRAP
210
PPAVAAREPP
220
LPPPPQPPAP
230
PQQQQPPPPQ
240
PQPPPEGGAV
250
RAGGAARPVS
260
LREVVRYLGG
270
SGGAGGRLTR
280
GRVQGLLEEE
290
AAARGRLERT
300
RLGALALPRG
310
DRPGRAPPAA
320
SARPSRSKRG
330
GEERVLEKEE
340
EEDDDEDEDE
350
EDDVSEGSEV
360
PESDRPAGAQ
370
HHQLNGERGP
380
QSAKERVKEW
390
TPCGPHQGQD
400
EGRGPAPGSG
410
TRQVFSMAAM
420
NKEGGTASVA
430
TGPDSPSPVP
440
LPPGKPALPG
450
ADGTPFGCPP
460
GRKEKPSDPV
470
EWTVMDVVEY
480
FTEAGFPEQA
490
TAFQEQEIDG
500
KSLLLMQRTD
510
VLTGLSIRLG
520
PALKIYEHHI
530
KVLQQGHFED
DDPDGFLG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0030169 | low-density lipoprotein particle binding |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0090077 | foam cell differentiation |
| Biological Process | GO:0034439 | lipoprotein lipid oxidation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0160217 | negative regulation of transcription initiation-coupled chromatin remodeling |
| Biological Process | GO:0051260 | protein homooligomerization |
Reference
PMID: N/A