Search Results

Overview

Uniprot IDQ6UB99
Protein NameAnkyrin repeat domain-containing protein 11
Gene NameANKRD11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
148 SQSTVCQKGTPNSAS
2325 KPTAEAPKAPRVEEI
2349 QMLANQSKQGPPPSE
38 KDKVSLTKTPKLERG
385 NSFISIPKMEVKSYT
389 SIPKMEVKSYTKNNT
393 MEVKSYTKNNTIAPK
608 RASLSEKKSPFLSSA
683 NDLSTENKLKVLKHD
685 LSTENKLKVLKHDRD
915 KDRDYLDKNSEKRKE
928 KEQTEKHKSVPGYLS

Function

Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity)

Protein Sequence

10 MPKGGCPKAP 20 QQEELPLSSD 30 MVEKQTGKKD 40 KDKVSLTKTP 50 KLERGDGGKE 60 VRERASKRKL 70 PFTAGANGEQ 80 KDSDTEKQGP 90 ERKRIKKEPV 100 TRKAGLLFGM 110 GLSGIRAGYP 120 LSERQQVALL 130 MQMTAEESAN 140 SPVDTTPKHP 150 SQSTVCQKGT 160 PNSASKTKDK 170 VNKRNERGET 180 RLHRAAIRGD 190 ARRIKELISE 200 GADVNVKDFA 210 GWTALHEACN 220 RGYYDVAKQL 230 LAAGAEVNTK 240 GLDDDTPLHD 250 AANNGHYKVV 260 KLLLRYGGNP 270 QQSNRKGETP 280 LKVANSPTMV 290 NLLLGKGTYT 300 SSEESSTESS 310 EEEDAPSFAP 320 SSSVDGNNTD 330 SEFEKGLKHK 340 AKNPEPQKAT 350 APVKDEYEFD 360 EDDEQDRVPP 370 VDDKHLLKKD 380 YRKETKSNSF 390 ISIPKMEVKS 400 YTKNNTIAPK 410 KASHRILSDT 420 SDEEDASVTV 430 GTGEKLRLSA 440 HTILPGSKTR 450 EPSNAKQQKE 460 KNKVKKKRKK 470 ETKGREVRFG 480 KRSDKFCSSE 490 SESESSESGE 500 DDRDSLGSSG 510 CLKGSPLVLK 520 DPSLFSSLSA 530 SSTSSHGSSA 540 AQKQNPSHTD 550 QHTKHWRTDN 560 WKTISSPAWS 570 EVSSLSDSTR 580 TRLTSESDYS 590 SEGSSVESLK 600 PVRKRQEHRK 610 RASLSEKKSP 620 FLSSAEGAVP 630 KLDKEGKVVK 640 KHKTKHKHKN 650 KEKGQCSISQ 660 ELKLKSFTYE 670 YEDSKQKSDK 680 AILLENDLST 690 ENKLKVLKHD 700 RDHFKKEEKL 710 SKMKLEEKEW 720 LFKDEKSLKR 730 IKDTNKDISR 740 SFREEKDRSN 750 KAEKERSLKE 760 KSPKEEKLRL 770 YKEERKKKSK 780 DRPSKLEKKN 790 DLKEDKISKE 800 KEKIFKEDKE 810 KLKKEKVYRE 820 DSAFDEYCNK 830 NQFLENEDTK 840 FSLSDDQRDR 850 WFSDLSDSSF 860 DFKGEDSWDS 870 PVTDYRDMKS 880 DSVAKLILET 890 VKEDSKERRR 900 DSRAREKRDY 910 REPFFRKKDR 920 DYLDKNSEKR 930 KEQTEKHKSV 940 PGYLSEKDKK 950 RRESAEAGRD 960 RKDALESCKE 970 RRDGRAKPEE 980 AHREELKECG 990 CESGFKDKSD 1000 GDFGKGLEPW 1010 ERHHPAREKE 1020 KKDGPDKERK 1030 EKTKPERYKE 1040 KSSDKDKSEK 1050 SILEKCQKDK 1060 EFDKCFKEKK 1070 DTKEKHKDTH 1080 GKDKERKASL 1090 DQGKEKKEKA 1100 FPGIISEDFS 1110 EKKDDKKGKE 1120 KSWYIADIFT 1130 DESEDDRDSC 1140 MGSGFKMGEA 1150 SDLPRTDGLQ 1160 EKEEGREAYA 1170 SDRHRKSSDK 1180 QHPERQKDKE 1190 PRDRRKDRGA 1200 ADAGRDKKEK 1210 VFEKHKEKKD 1220 KESTEKYKDR 1230 KDRASVDSTQ 1240 DKKNKQKLPE 1250 KAEKKHAAED 1260 KAKSKHKEKS 1270 DKEHSKERKS 1280 SRSADAEKSL 1290 LEKLEEEALH 1300 EYREDSNDKI 1310 SEVSSDSFTD 1320 RGQEPGLTAF 1330 LEVSFTEPPG 1340 DDKPRESACL 1350 PEKLKEKERH 1360 RHSSSSSKKS 1370 HDRERAKKEK 1380 AEKKEKGEDY 1390 KEGGSRKDSG 1400 QYEKDFLEAD 1410 AYGVSYNMKA 1420 DIEDELDKTI 1430 ELFSTEKKDK 1440 NDSEREPSKK 1450 IEKELKPYGS 1460 SAINILKEKK 1470 KREKHREKWR 1480 DEKERHRDRH 1490 ADGLLRHHRD 1500 ELLRHHRDEQ 1510 KPATRDKDSP 1520 PRVLKDKSRD 1530 EGPRLGDAKL 1540 KEKFKDGAEK 1550 EKGDPVKMSN 1560 GNDKVAPSKD 1570 PGKKDARPRE 1580 KLLGDGDLMM 1590 TSFERMLSQK 1600 DLEIEERHKR 1610 HKERMKQMEK 1620 LRHRSGDPKL 1630 KEKAKPADDG 1640 RKKGLDIPAK 1650 KPPGLDPPFK 1660 DKKLKESTPI 1670 PPAAENKLHP 1680 ASGADSKDWL 1690 AGPHMKEVLP 1700 ASPRPDQSRP 1710 TGVPTPTSVL 1720 SCPSYEEVMH 1730 TPRTPSCSAD 1740 DYADLVFDCA 1750 DSQHSTPVPT 1760 APTSACSPSF 1770 FDRFSVASSG 1780 LSENASQAPA 1790 RPLSTNLYRS 1800 VSVDIRRTPE 1810 EEFSVGDKLF 1820 RQQSVPAASS 1830 YDSPMPPSME 1840 DRAPLPPVPA 1850 EKFACLSPGY 1860 YSPDYGLPSP 1870 KVDALHCPPA 1880 AVVTVTPSPE 1890 GVFSSLQAKP 1900 SPSPRAELLV 1910 PSLEGALPPD 1920 LDTSEDQQAT 1930 AAIIPPEPSY 1940 LEPLDEGPFS 1950 AVITEEPVEW 1960 AHPSEQALAS 1970 SLIGGTSENP 1980 VSWPVGSDLL 1990 LKSPQRFPES 2000 PKRFCPADPL 2010 HSAAPGPFSA 2020 SEAPYPAPPA 2030 SPAPYALPVA 2040 EPGLEDVKDG 2050 VDAVPAAIST 2060 SEAAPYAPPS 2070 GLESFFSNCK 2080 SLPEAPLDVA 2090 PEPACVAAVA 2100 QVEALGPLEN 2110 SFLDGSRGLS 2120 HLGQVEPVPW 2130 ADAFAGPEDD 2140 LDLGPFSLPE 2150 LPLQTKDAAD 2160 GEAEPVEESL 2170 APPEEMPPGA 2180 PGVINGGDVS 2190 TVVAEEPPAL 2200 PPDQASTRLP 2210 AELEPEPSGE 2220 PKLDVALEAA 2230 VEAETVPEER 2240 ARGDPDSSVE 2250 PAPVPPEQRP 2260 LGSGDQGAEA 2270 EGPPAASLCA 2280 PDGPAPNTVA 2290 QAQAADGAGP 2300 EDDTEASRAA 2310 APAEGPPGGI 2320 QPEAAEPKPT 2330 AEAPKAPRVE 2340 EIPQRMTRNR 2350 AQMLANQSKQ 2360 GPPPSEKECA 2370 PTPAPVTRAK 2380 ARGSEDDDAQ 2390 AQHPRKRRFQ 2400 RSTQQLQQQL 2410 NTSTQQTREV 2420 IQQTLAAIVD 2430 AIKLDAIEPY 2440 HSDRANPYFE 2450 YLQIRKKIEE 2460 KRKILCCITP 2470 QAPQCYAEYV 2480 TYTGSYLLDG 2490 KPLSKLHIPV 2500 IAPPPSLAEP 2510 LKELFRQQEA 2520 VRGKLRLQHS 2530 IEREKLIVSC 2540 EQEILRVHCR 2550 AARTIANQAV 2560 PFSACTMLLD 2570 SEVYNMPLES 2580 QGDENKSVRD 2590 RFNARQFISW 2600 LQDVDDKYDR 2610 MKTCLLMRQQ 2620 HEAAALNAVQ 2630 RMEWQLKVQE 2640 LDPAGHKSLC 2650 VNEVPSFYVP 2660 MVDVNDDFVL LPA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0048705 skeletal system morphogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.