Search Results

Overview

Uniprot IDQ6UUV7
Protein NameCREB-regulated transcription coactivator 3
Gene NameCRTC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
49 LSRVQFQKLQQLRLT

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)

Protein Sequence

10 MAASPGSGSA 20 NPRKFSEKIA 30 LHTQRQAEET 40 RAFEQLMTDL 50 TLSRVQFQKL 60 QQLRLTQYHG 70 GSLPNVSQLR 80 SSASEFQPSF 90 HQADNVRGTR 100 HHGLVERPSR 110 NRFHPLHRRS 120 GDKPGRQFDG 130 SAFGANYSSQ 140 PLDESWPRQQ 150 PPWKDEKHPG 160 FRLTSALNRT 170 NSDSALHTSA 180 LSTKPQDPYG 190 GGGQSAWPAP 200 YMGFCDGENN 210 GHGEVASFPG 220 PLKEENLLNV 230 PKPLPKQLWE 240 TKEIQSLSGR 250 PRSCDVGGGN 260 AFPHNGQNLG 270 LSPFLGTLNT 280 GGSLPDLTNL 290 HYSTPLPASL 300 DTTDHHFGSM 310 SVGNSVNNIP 320 AAMTHLGIRS 330 SSGLQSSRSN 340 PSIQATLNKT 350 VLSSSLNNHP 360 QTSVPNASAL 370 HPSLRLFSLS 380 NPSLSTTNLS 390 GPSRRRQPPV 400 SPLTLSPGPE 410 AHQGFSRQLS 420 STSPLAPYPT 430 SQMVSSDRSQ 440 LSFLPTEAQA 450 QVSPPPPYPA 460 PQELTQPLLQ 470 QPRAPEAPAQ 480 QPQAASSLPQ 490 SDFQLLPAQG 500 SSLTNFFPDV 510 GFDQQSMRPG 520 PAFPQQVPLV 530 QQGSRELQDS 540 FHLRPSPYSN 550 CGSLPNTILP 560 EDSSTSLFKD 570 LNSALAGLPE 580 VSLNVDTPFP 590 LEEELQIEPL 600 SLDGLNMLSD 610 SSMGLLDPSV EETFRADRL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008140 cAMP response element binding protein binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042116 macrophage activation
Biological Process GO:0071878 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051289 protein homotetramerization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.