Overview
| Uniprot ID | Q6UVJ0 |
|---|
| Protein Name | Spindle assembly abnormal protein 6 homolog |
|---|
| Gene Name | SASS6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 455 |
EQLEATVKKLEESKQ |
| 461 |
VKKLEESKQLLKNNE |
Function
Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853)
Protein Sequence
10
MSQVLFHQLV
20
PLQVKCKDCE
30
ERRVSIRMSI
40
ELQSVSNPVH
50
RKDLVIRLTD
60
DTDPFFLYNL
70
VISEEDFQSL
80
KFQQGLLVDF
90
LAFPQKFIDL
100
LQQCTQEHAK
110
EIPRFLLQLV
120
SPAAILDNSP
130
AFLNVVETNP
140
FKHLTHLSLK
150
LLPGNDVEIK
160
KFLAGCLKCS
170
KEEKLSLMQS
180
LDDATKQLDF
190
TRKTLAEKKQ
200
ELDKLRNEWA
210
SHTAALTNKH
220
SQELTNEKEK
230
ALQAQVQYQQ
240
QHEQQKKDLE
250
ILHQQNIHQL
260
QNRLSELEAA
270
NKDLTERKYK
280
GDSTIRELKA
290
KLSGVEEELQ
300
RTKQEVLSLR
310
RENSTLDVEC
320
HEKEKHVNQL
330
QTKVAVLEQE
340
IKDKDQLVLR
350
TKEAFDTIQE
360
QKVVLEENGE
370
KNQVQLGKLE
380
ATIKSLSAEL
390
LKANEIIKKL
400
QGDLKTLMGK
410
LKLKNTVTIQ
420
QEKLLAEKEE
430
KLQKEQKELQ
440
DVGQSLRIKE
450
QEVCKLQEQL
460
EATVKKLEES
470
KQLLKNNEKL
480
ITWLNKELNE
490
NQLVRKQDVL
500
GPSTTPPAHS
510
SSNTIRSGIS
520
PNLNVVDGRL
530
TYPTCGIGYP
540
VSSAFAFQNT
550
FPHSISAKNT
560
SHPGSGTKVQ
570
FNLQFTKPNA
580
SLGDVQSGAT
590
ISMPCSTDKE
600
NGENVGLESK
610
YLKKREDSIP
620
LRGLSQNLFS
630
NSDHQRDGTL
640
GALHTSSKPT
650
ALPSASSAYF
PGQLPNS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005814 |
centriole |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0098536 |
deuterosome |
| Biological Process |
GO:0007099 |
centriole replication |
| Biological Process |
GO:0051298 |
centrosome duplication |
| Biological Process |
GO:0046601 |
positive regulation of centriole replication |
| Biological Process |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process |
GO:1905832 |
positive regulation of spindle assembly |
| Biological Process |
GO:0060236 |
regulation of mitotic spindle organization |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.