Overview
| Uniprot ID | Q6UWP2 |
|---|
| Protein Name | Dehydrogenase/reductase SDR family member 11 |
|---|
| Gene Name | DHRS11 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 228 |
YEQMKCLKPEDVAEA |
Function
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids (PubMed:26920053). May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively (PubMed:31926269). May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones (PubMed:26920053)
Protein Sequence
10
MARPGMERWR
20
DRLALVTGAS
30
GGIGAAVARA
40
LVQQGLKVVG
50
CARTVGNIEE
60
LAAECKSAGY
70
PGTLIPYRCD
80
LSNEEDILSM
90
FSAIRSQHSG
100
VDICINNAGL
110
ARPDTLLSGS
120
TSGWKDMFNV
130
NVLALSICTR
140
EAYQSMKERN
150
VDDGHIININ
160
SMSGHRVLPL
170
SVTHFYSATK
180
YAVTALTEGL
190
RQELREAQTH
200
IRATCISPGV
210
VETQFAFKLH
220
DKDPEKAAAT
230
YEQMKCLKPE
240
DVAEAVIYVL
250
STPAHIQIGD
260
IQMRPTEQVT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005576 |
extracellular region |
| Molecular Function |
GO:0072582 |
17-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0000253 |
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0000166 |
nucleotide binding |
| Biological Process |
GO:0006703 |
estrogen biosynthetic process |
| Biological Process |
GO:0006694 |
steroid biosynthetic process |
Reference
PMID: N/A