Search Results
Overview
| Uniprot ID | Q6UWZ7 |
|---|---|
| Protein Name | BRCA1-A complex subunit Abraxas 1 |
| Gene Name | ABRAXAS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 347 | TPQIIKHKALDLDDR |
| 368 | RLLDTQDKRSKADTG |
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX
Protein Sequence
10
MEGESTSAVL
20
SGFVLGALAF
30
QHLNTDSDTE
40
GFLLGEVKGE
50
AKNSITDSQM
60
DDVEVVYTID
70
IQKYIPCYQL
80
FSFYNSSGEV
90
NEQALKKILS
100
NVKKNVVGWY
110
KFRRHSDQIM
120
TFRERLLHKN
130
LQEHFSNQDL
140
VFLLLTPSII
150
TESCSTHRLE
160
HSLYKPQKGL
170
FHRVPLVVAN
180
LGMSEQLGYK
190
TVSGSCMSTG
200
FSRAVQTHSS
210
KFFEEDGSLK
220
EVHKINEMYA
230
SLQEELKSIC
240
KKVEDSEQAV
250
DKLVKDVNRL
260
KREIEKRRGA
270
QIQAAREKNI
280
QKDPQENIFL
290
CQALRTFFPN
300
SEFLHSCVMS
310
LKNRHVSKSS
320
CNYNHHLDVV
330
DNLTLMVEHT
340
DIPEASPAST
350
PQIIKHKALD
360
LDDRWQFKRS
370
RLLDTQDKRS
380
KADTGSSNQD
390
KASKMSSPET
400
DEEIEKMKGF
GEYSRSPTF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070531 | BRCA1-A complex |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0031593 | polyubiquitin modification-dependent protein binding |
| Biological Process | GO:0008608 | attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006302 | double-strand break repair |
| Biological Process | GO:0007095 | mitotic G2 DNA damage checkpoint signaling |
| Biological Process | GO:0044818 | mitotic G2/M transition checkpoint |
| Biological Process | GO:0090307 | mitotic spindle assembly |
| Biological Process | GO:0045739 | positive regulation of DNA repair |
| Biological Process | GO:0006282 | regulation of DNA repair |
| Biological Process | GO:0010212 | response to ionizing radiation |
Reference
PMID: N/A