Search Results

Overview

Uniprot IDQ6UX04
Protein NameSpliceosome-associated protein CWC27 homolog
Gene NameCWC27
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
228 VSQSMKGKSKSSHDL
230 QSMKGKSKSSHDLLK
298 KDTSANVKSAGEGEV
331 KRELLAAKQKKVENA
333 ELLAAKQKKVENAAK
366 EYRREKQKYEALRKQ
393 LALLNQFKSKLTQAI
395 LLNQFKSKLTQAIAE

Function

As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Protein Sequence

10 MSNIYIQEPP 20 TNGKVLLKTT 30 AGDIDIELWS 40 KEAPKACRNF 50 IQLCLEAYYD 60 NTIFHRVVPG 70 FIVQGGDPTG 80 TGSGGESIYG 90 APFKDEFHSR 100 LRFNRRGLVA 110 MANAGSHDNG 120 SQFFFTLGRA 130 DELNNKHTIF 140 GKVTGDTVYN 150 MLRLSEVDID 160 DDERPHNPHK 170 IKSCEVLFNP 180 FDDIIPREIK 190 RLKKEKPEEE 200 VKKLKPKGTK 210 NFSLLSFGEE 220 AEEEEEEVNR 230 VSQSMKGKSK 240 SSHDLLKDDP 250 HLSSVPVVES 260 EKGDAPDLVD 270 DGEDESAEHD 280 EYIDGDEKNL 290 MRERIAKKLK 300 KDTSANVKSA 310 GEGEVEKKSV 320 SRSEELRKEA 330 RQLKRELLAA 340 KQKKVENAAK 350 QAEKRSEEEE 360 APPDGAVAEY 370 RREKQKYEAL 380 RKQQSKKGTS 390 REDQTLALLN 400 QFKSKLTQAI 410 AETPENDIPE 420 TEVEDDEGWM 430 SHVLQFEDKS 440 RKVKDASMQD 450 SDTFEIYDPR 460 NPVNKRRREE 470 SKKLMREKKE RR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0006457 protein folding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.