Search Results

Overview

Uniprot ID	Q6UX53
Protein Name	Thiol S-methyltransferase TMT1B
Gene Name	TMT1B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
109	HFEKFLTKSMAENRH
155	CSVQSPRKVLQEVRR
63	RELFSQIKGLTGASG

Function

Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol

Protein Sequence

10 MDILVPLLQL 20 LVLLLTLPLH 30 LMALLGCWQP 40 LCKSYFPYLM 50 AVLTPKSNRK 60 MESKKRELFS 70 QIKGLTGASG 80 KVALLELGCG 90 TGANFQFYPP 100 GCRVTCLDPN 110 PHFEKFLTKS 120 MAENRHLQYE 130 RFVVAPGEDM 140 RQLADGSMDV 150 VVCTLVLCSV 160 QSPRKVLQEV 170 RRVLRPGGVL 180 FFWEHVAEPY 190 GSWAFMWQQV 200 FEPTWKHIGD 210 GCCLTRETWK 220 DLENAQFSEI 230 QMERQPPPLK 240 WLPVGPHIMG KAVK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005811	lipid droplet
Molecular Function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
Molecular Function	GO:0018708	thiol S-methyltransferase activity
Biological Process	GO:0032259	methylation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.