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Overview

Uniprot IDQ6VMQ6
Protein NameActivating transcription factor 7-interacting protein 1
Gene NameATF7IP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
588 FQVKITAKGDINQKL
910 NRGPIQMKIPISAFS

Function

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100)

Protein Sequence

10 MDSLEEPQKK 20 VFKARKTMRV 30 SDRQQLEAVY 40 KVKEELLKTD 50 VKLLNGNHEN 60 GDLDPTSPLE 70 NMDYIKDKEE 80 VNGIEEICFD 90 PEGSKAEWKE 100 TPCILSVNVK 110 NKQDDDLNCE 120 PLSPHNITPE 130 PVSKLPAEPV 140 SGDPAPGDLD 150 AGDPASGVLA 160 SGDSTSGDPT 170 SSEPSSSDAA 180 SGDATSGDAP 190 SGDVSPGDAT 200 SGDATADDLS 210 SGDPTSSDPI 220 PGEPVPVEPI 230 SGDCAADDIA 240 SSEITSVDLA 250 SGAPASTDPA 260 SDDLASGDLS 270 SSELASDDLA 280 TGELASDELT 290 SESTFDRTFE 300 PKSVPVCEPV 310 PEIDNIEPSS 320 NKDDDFLEKN 330 GADEKLEQIQ 340 SKDSLDEKNK 350 ADNNIDANEE 360 TLETDDTTIC 370 SDRPPENEKK 380 VEEDIITELA 390 LGEDAISSSM 400 EIDQGEKNED 410 ETSADLVETI 420 NENVIEDNKS 430 ENILENTDSM 440 ETDEIIPILE 450 KLAPSEDELT 460 CFSKTSLLPI 470 DETNPDLEEK 480 MESSFGSPSK 490 QESSESLPKE 500 AFLVLSDEED 510 ISGEKDESEV 520 ISQNETCSPA 530 EVESNEKDNK 540 PEEEEQVIHE 550 DDERPSEKNE 560 FSRRKRSKSE 570 DMDNVQSKRR 580 RYMEEEYEAE 590 FQVKITAKGD 600 INQKLQKVIQ 610 WLLEEKLCAL 620 QCAVFDKTLA 630 ELKTRVEKIE 640 CNKRHKTVLT 650 ELQAKIARLT 660 KRFEAAKEDL 670 KKRHEHPPNP 680 PVSPGKTVND 690 VNSNNNMSYR 700 NAGTVRQMLE 710 SKRNVSESAP 720 PSFQTPVNTV 730 SSTNLVTPPA 740 VVSSQPKLQT 750 PVTSGSLTAT 760 SVLPAPNTAT 770 VVATTQVPSG 780 NPQPTISLQP 790 LPVILHVPVA 800 VSSQPQLLQS 810 HPGTLVTNQP 820 SGNVEFISVQ 830 SPPTVSGLTK 840 NPVSLPSLPN 850 PTKPNNVPSV 860 PSPSIQRNPT 870 ASAAPLGTTL 880 AVQAVPTAHS 890 IVQATRTSLP 900 TVGPSGLYSP 910 STNRGPIQMK 920 IPISAFSTSS 930 AAEQNSNTTP 940 RIENQTNKTI 950 DASVSKKAAD 960 STSQCGKATG 970 SDSSGVIDLT 980 MDDEESGASQ 990 DPKKLNHTPV 1000 STMSSSQPVS 1010 RPLQPIQPAP 1020 PLQPSGVPTS 1030 GPSQTTIHLL 1040 PTAPTTVNVT 1050 HRPVTQVTTR 1060 LPVPRAPANH 1070 QVVYTTLPAP 1080 PAQAPLRGTV 1090 MQAPAVRQVN 1100 PQNSVTVRVP 1110 QTTTYVVNNG 1120 LTLGSTGPQL 1130 TVHHRPPQVH 1140 TEPPRPVHPA 1150 PLPEAPQPQR 1160 LPPEAASTSL 1170 PQKPHLKLAR 1180 VQSQNGIVLS 1190 WSVLEVDRSC 1200 ATVDSYHLYA 1210 YHEEPSATVP 1220 SQWKKIGEVK 1230 ALPLPMACTL 1240 TQFVSGSKYY 1250 FAVRAKDIYG 1260 RFGPFCDPQS 1270 TDVISSTQSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006346 DNA methylation-dependent constitutive heterochromatin formation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

PMID: N/A