Search Results

Overview

Uniprot IDQ6VY07
Protein NamePhosphofurin acidic cluster sorting protein 1
Gene NamePACS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
317 KVKKTRRKLTSTSAI
333 RQPNIKQKFVALLKR
339 QKFVALLKRFKVSDE
487 KTPMKSSKTDLQGSA
885 VTKEKNKKVPTIFLS

Function

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity)

Protein Sequence

10 MAERGGAGGG 20 PGGAGGGSGQ 30 RGSGVAQSPQ 40 QPPPQQQQQQ 50 PPQQPTPPKL 60 AQATSSSSST 70 SAAAASSSSS 80 STSTSMAVAV 90 ASGSAPPGGP 100 GPGRTPAPVQ 110 MNLYATWEVD 120 RSSSSCVPRL 130 FSLTLKKLVM 140 LKEMDKDLNS 150 VVIAVKLQGS 160 KRILRSNEIV 170 LPASGLVETE 180 LQLTFSLQYP 190 HFLKRDANKL 200 QIMLQRRKRY 210 KNRTILGYKT 220 LAVGLINMAE 230 VMQHPNEGAL 240 VLGLHSNVKD 250 VSVPVAEIKI 260 YSLSSQPIDH 270 EGIKSKLSDR 280 SPDIDNYSEE 290 EEESFSSEQE 300 GSDDPLHGQD 310 LFYEDEDLRK 320 VKKTRRKLTS 330 TSAITRQPNI 340 KQKFVALLKR 350 FKVSDEVGFG 360 LEHVSREQIR 370 EVEEDLDELY 380 DSLEMYNPSD 390 SGPEMEETES 400 ILSTPKPKLK 410 PFFEGMSQSS 420 SQTEIGSLNS 430 KGSLGKDTTS 440 PMELAALEKI 450 KSTWIKNQDD 460 SLTETDTLEI 470 TDQDMFGDAS 480 TSLVVPEKVK 490 TPMKSSKTDL 500 QGSASPSKVE 510 GVHTPRQKRS 520 TPLKERQLSK 530 PLSERTNSSD 540 SERSPDLGHS 550 TQIPRKVVYD 560 QLNQILVSDA 570 ALPENVILVN 580 TTDWQGQYVA 590 ELLQDQRKPV 600 VCTCSTVEVQ 610 AVLSALLTRI 620 QRYCNCNSSM 630 PRPVKVAAVG 640 GQSYLSSILR 650 FFVKSLANKT 660 SDWLGYMRFL 670 IIPLGSHPVA 680 KYLGSVDSKY 690 SSSFLDSGWR 700 DLFSRSEPPV 710 SEQLDVAGRV 720 MQYVNGAATT 730 HQLPVAEAML 740 TCRHKFPDED 750 SYQKFIPFIG 760 VVKVGLVEDS 770 PSTAGDGDDS 780 PVVSLTVPST 790 SPPSSSGLSR 800 DATATPPSSP 810 SMSSALAIVG 820 SPNSPYGDVI 830 GLQVDYWLGH 840 PGERRREGDK 850 RDASSKNTLK 860 SVFRSVQVSR 870 LPHSGEAQLS 880 GTMAMTVVTK 890 EKNKKVPTIF 900 LSKKPREKEV 910 DSKSQVIEGI 920 SRLICSAKQQ 930 QTMLRVSIDG 940 VEWSDIKFFQ 950 LAAQWPTHVK 960 HFPVGLFSGS KAT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030137 COPI-coated vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0002260 lymphocyte homeostasis
Biological Process GO:0072659 protein localization to plasma membrane

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.