Search Results

Overview

Uniprot ID	Q6W2J9
Protein Name	BCL-6 corepressor
Gene Name	BCOR
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1045	TKDSEMCKFSPADWE
1061	LKGNQDKKPKSVTLE
1063	GNQDKKPKSVTLEEA
1206	ELTGLHPKKQRHLLH
1305	STSAGGKKQAQPSCA
1325	PAKQQKIKENQKTDV
1329	QKIKENQKTDVLCAD
1360	NSEKPSGKRLCKTKH
1366	GKRLCKTKHLIPQES
1399	VTVRRFRKRPEPSSD
1460	ARRLIVNKNAGETLL
157	KTPPGIQKSAVATAE
40	VNDGDASKARLELRE
460	SKADHMKKMAPTVLV
530	KSMSLKNKALDWAIP
774	ILETSSTKLHPDVPT
872	FHETYTFKQPVFTVS
958	DGKVLKPKPSKLAKR

Function

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2)

Protein Sequence

10 MLSATPLYGN 20 VHSWMNSERV 30 RMCGASEDRK 40 ILVNDGDASK 50 ARLELREENP 60 LNHNVVDAST 70 AHRIDGLAAL 80 SMDRTGLIRE 90 GLRVPGNIVY 100 SSLCGLGSEK 110 GREAATSTLG 120 GLGFSSERNP 130 EMQFKPNTPE 140 TVEASAVSGK 150 PPNGFSAIYK 160 TPPGIQKSAV 170 ATAEALGLDR 180 PASDKQSPLN 190 INGASYLRLP 200 WVNPYMEGAT 210 PAIYPFLDSP 220 NKYSLNMYKA 230 LLPQQSYSLA 240 QPLYSPVCTN 250 GERFLYLPPP 260 HYVGPHIPSS 270 LASPMRLSTP 280 SASPAIPPLV 290 HCADKSLPWK 300 MGVSPGNPVD 310 SHAYPHIQNS 320 KQPRVPSAKA 330 VTSGLPGDTA 340 LLLPPSPRPS 350 PRVHLPTQPA 360 ADTYSEFHKH 370 YARISTSPSV 380 ALSKPYMTVS 390 SEFPAARLSN 400 GKYPKAPEGG 410 EGAQPVPGHA 420 RKTAVQDRKD 430 GSSPPLLEKQ 440 TVTKDVTDKP 450 LDLSSKVVDV 460 DASKADHMKK 470 MAPTVLVHSR 480 AGSGLVLSGS 490 EIPKETLSPP 500 GNGCAIYRSE 510 IISTAPSSWV 520 VPGPSPNEEN 530 NGKSMSLKNK 540 ALDWAIPQQR 550 SSSCPRMGGT 560 DAVITNVSGS 570 VSSAGRPASA 580 SPAPNANADG 590 TKTSRSSVET 600 TPSVIQHVGQ 610 PPATPAKHSS 620 STSSKGAKAS 630 NPEPSFKANE 640 NGLPPSSIFL 650 SPNEAFRSPP 660 IPYPRSYLPY 670 PAPEGIAVSP 680 LSLHGKGPVY 690 PHPVLLPNGS 700 LFPGHLAPKP 710 GLPYGLPTGR 720 PEFVTYQDAL 730 GLGMVHPMLI 740 PHTPIEITKE 750 EKPERRSRSH 760 ERARYEDPTL 770 RNRFSEILET 780 SSTKLHPDVP 790 TDKNLKPNPN 800 WNQGKTVVKS 810 DKLVYVDLLR 820 EEPDAKTDTN 830 VSKPSFAAES 840 VGQSAEPPKP 850 SVEPALQQHR 860 DFIALREELG 870 RISDFHETYT 880 FKQPVFTVSK 890 DSVLAGTNKE 900 NLGLPVSTPF 910 LEPPLGSDGP 920 AVTFGKTQED 930 PKPFCVGSAP 940 PSVDVTPTYT 950 KDGADEAESN 960 DGKVLKPKPS 970 KLAKRIANSA 980 GYVGDRFKCV 990 TTELYADSSQ 1000 LSREQRALQM 1010 EGLQEDSILC 1020 LPAAYCERAM 1030 MRFSELEMKE 1040 REGGHPATKD 1050 SEMCKFSPAD 1060 WERLKGNQDK 1070 KPKSVTLEEA 1080 IAEQNESERC 1090 EYSVGNKHRD 1100 PFEAPEDKDL 1110 PVEKYFVERQ 1120 PVSEPPADQV 1130 ASDMPHSPTL 1140 RVDRKRKVSG 1150 DSSHTETTAE 1160 EVPEDPLLKA 1170 KRRRVSKDDW 1180 PEREMTNSSS 1190 NHLEDPHYSE 1200 LTNLKVCIEL 1210 TGLHPKKQRH 1220 LLHLRERWEQ 1230 QVSAADGKPG 1240 RQSRKEVTQA 1250 TQPEAIPQGT 1260 NITEEKPGRK 1270 RAEAKGNRSW 1280 SEESLKPSDN 1290 EQGLPVFSGS 1300 PPMKSLSSTS 1310 AGGKKQAQPS 1320 CAPASRPPAK 1330 QQKIKENQKT 1340 DVLCADEEED 1350 CQAASLLQKY 1360 TDNSEKPSGK 1370 RLCKTKHLIP 1380 QESRRGLPLT 1390 GEYYVENADG 1400 KVTVRRFRKR 1410 PEPSSDYDLS 1420 PAKQEPKPFD 1430 RLQQLLPASQ 1440 STQLPCSSSP 1450 QETTQSRPMP 1460 PEARRLIVNK 1470 NAGETLLQRA 1480 ARLGYEEVVL 1490 YCLENKICDV 1500 NHRDNAGYCA 1510 LHEACARGWL 1520 NIVRHLLEYG 1530 ADVNCSAQDG 1540 TRPLHDAVEN 1550 DHLEIVRLLL 1560 SYGADPTLAT 1570 YSGRTIMKMT 1580 HSELMEKFLT 1590 DYLNDLQGRN 1600 DDDASGTWDF 1610 YGSSVCEPDD 1620 ESGYDVLANP 1630 PGPEDQDDDD 1640 DAYSDVFEFE 1650 FSETPLLPCY 1660 NIQVSVAQGP 1670 RNWLLLSDVL 1680 KKLKMSSRIF 1690 RCNFPNVEIV 1700 TIAEAEFYRQ 1710 VSASLLFSCS 1720 KDLEAFNPES 1730 KELLDLVEFT 1740 NEIQTLLGSS 1750 VEWLHPSDLA SDNYW

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0140261	BCOR complex
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0031072	heat shock protein binding
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0000976	transcription cis-regulatory region binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007507	heart development
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0030502	negative regulation of bone mineralization
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0070171	negative regulation of tooth mineralization
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0042476	odontogenesis
Biological Process	GO:0060021	roof of mouth development
Biological Process	GO:0065001	specification of axis polarity

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.