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Overview

Uniprot IDQ6WCQ1
Protein NameMyosin phosphatase Rho-interacting protein
Gene NameMPRIP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
161 QNQKKKRKVEPPTPQ
200 AEKVPTTKSTLWQEE
306 RRSQVIEKFEALDIE
541 RRREGRSKTFDWAEF

Function

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells

Protein Sequence

10 MSAAKENPCR 20 KFQANIFNKS 30 KCQNCFKPRE 40 SHLLNDEDLT 50 QAKPIYGGWL 60 LLAPDGTDFD 70 NPVHRSRKWQ 80 RRFFILYEHG 90 LLRYALDEMP 100 TTLPQGTINM 110 NQCTDVVDGE 120 GRTGQKFSLC 130 ILTPEKEHFI 140 RAETKEIVSG 150 WLEMLMVYPR 160 TNKQNQKKKR 170 KVEPPTPQEP 180 GPAKVAVTSS 190 SSSSSSSSSI 200 PSAEKVPTTK 210 STLWQEEMRT 220 KDQPDGSSLS 230 PAQSPSQSQP 240 PAASSLREPG 250 LESKEEESAM 260 SSDRMDCGRK 270 VRVESGYFSL 280 EKTKQDLKAE 290 EQQLPPPLSP 300 PSPSTPNHRR 310 SQVIEKFEAL 320 DIEKAEHMET 330 NAVGPSPSSD 340 TRQGRSEKRA 350 FPRKRDFTNE 360 APPAPLPDAS 370 ASPLSPHRRA 380 KSLDRRSTEP 390 SVTPDLLNFK 400 KGWLTKQYED 410 GQWKKHWFVL 420 ADQSLRYYRD 430 SVAEEAADLD 440 GEIDLSACYD 450 VTEYPVQRNY 460 GFQIHTKEGE 470 FTLSAMTSGI 480 RRNWIQTIMK 490 HVHPTTAPDV 500 TSSLPEEKNK 510 SSCSFETCPR 520 PTEKQEAELG 530 EPDPEQKRSR 540 ARERRREGRS 550 KTFDWAEFRP 560 IQQALAQERV 570 GGVGPADTHE 580 PLRPEAEPGE 590 LERERARRRE 600 ERRKRFGMLD 610 ATDGPGTEDA 620 ALRMEVDRSP 630 GLPMSDLKTH 640 NVHVEIEQRW 650 HQVETTPLRE 660 EKQVPIAPVH 670 LSSEDGGDRL 680 STHELTSLLE 690 KELEQSQKEA 700 SDLLEQNRLL 710 QDQLRVALGR 720 EQSAREGYVL 730 QATCERGFAA 740 MEETHQKKIE 750 DLQRQHQREL 760 EKLREEKDRL 770 LAEETAATIS 780 AIEAMKNAHR 790 EEMERELEKS 800 QRSQISSVNS 810 DVEALRRQYL 820 EELQSVQREL 830 EVLSEQYSQK 840 CLENAHLAQA 850 LEAERQALRQ 860 CQRENQELNA 870 HNQELNNRLA 880 AEITRLRTLL 890 TGDGGGEATG 900 SPLAQGKDAY 910 ELEVLLRVKE 920 SEIQYLKQEI 930 SSLKDELQTA 940 LRDKKYASDK 950 YKDIYTELSI 960 AKAKADCDIS 970 RLKEQLKAAT 980 EALGEKSPDS 990 ATVSGYDIMK 1000 SKSNPDFLKK 1010 DRSCVTRQLR 1020 NIRSKSVIEQ VSWDT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005925 focal adhesion
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0042802 identical protein binding

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.