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Overview

Uniprot IDQ6WKZ4
Protein NameRab11 family-interacting protein 1
Gene NameRAB11FIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
172 KSRNPFGKLKDKIKG
223 KIKTLLSKSNLQKTP

Function

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412)

Protein Sequence

10 MSLMVSAGRG 20 LGAVWSPTHV 30 QVTVLQARGL 40 RAKGPGGTSD 50 AYAVIQVGKE 60 KYATSVSERS 70 LGAPVWREEA 80 TFELPSLLSS 90 GPAAAATLQL 100 TVLHRALLGL 110 DKFLGRAEVD 120 LRDLHRDQGR 130 RKTQWYKLKS 140 KPGKKDKERG 150 EIEVDIQFMR 160 NNMTASMFDL 170 SMKDKSRNPF 180 GKLKDKIKGK 190 NKDSGSDTAS 200 AIIPSTTPSV 210 DSDDESVVKD 220 KKKKSKIKTL 230 LSKSNLQKTP 240 LSQSMSVLPT 250 SKPEKVLLRP 260 GDFQSQWDED 270 DNEDESSSAS 280 DVMSHKRTAS 290 TDLKQLNQVN 300 FTLPKKEGLS 310 FLGGLRSKND 320 VLSRSNVCIN 330 GNHVYLEQPE 340 AKGEIKDSSP 350 SSSPSPKGFR 360 KKHLFSSTEN 370 LAAGSWKEPA 380 EGGGLSSDRQ 390 LSESSTKDSL 400 KSMTLPSYRP 410 APLVSGDLRE 420 NMAPANSEAT 430 KEAKESKKPE 440 SRRSSLLSLM 450 TGKKDVAKGS 460 EGENPLTVPG 470 REKEGMLMGV 480 KPGEDASGPA 490 EDLVRRSEKD 500 TAAVVSRQGS 510 SLNLFEDVQI 520 TEPEAEPESK 530 SEPRPPISSP 540 RAPQTRAVKP 550 RLEVSPEAQP 560 TARLPSPTDS 570 PSSLPPLPSS 580 SGQASVPSEL 590 GHGADTQSSE 600 SPSVFSSLSS 610 PIAAPISTST 620 PIESWPLVDR 630 GQAKSEGPPL 640 LPKAELQTES 650 LTPVPNSGSS 660 ALGSLFKQPS 670 FPANKGTEDS 680 LMGRTRETGT 690 EKNTSSLELE 700 ESLPEQPETG 710 RQEEELPRFP 720 CKKQDYSPSS 730 GEAQEVPFAL 740 SLSSDGAVSP 750 VGELAAGGDR 760 DLESQAGSLV 770 ESKARDAAEE 780 VAPPLPMGAS 790 VPSIDSMMRK 800 LEEMGLNLRK 810 DQKKTKKRVS 820 FSEQLFTEEA 830 VAGAALLVEG 840 HSSCPQELNP 850 AWSVAGNASD 860 GEPPESPHAE 870 DSERESVTTP 880 GPATCGAPAS 890 PADHLLLPSQ 900 EESFSEVPMS 910 EASSAKDTPL 920 FRMEGEDALV 930 TQYQSKASDH 940 EGLLSDPLSD 950 LQLVSDFKSP 960 IMADLNLSLP 970 SIPEVASDDE 980 RIDQVEDDGD 990 QVEDDGETAK 1000 SSTLDIGALS 1010 LGLVVPCPER 1020 GKGPSGEADR 1030 LVLGEGLCDF 1040 RLQAPQASVT 1050 APSEQTTEFG 1060 IHKPHLGKSS 1070 SLDKQLPGPS 1080 GGEEEKPMGN 1090 GSPSPPPGTS 1100 LDNPVPSPSP 1110 SEIFPVTHSF 1120 PSSAHSDTHH 1130 TSTAESQKKA 1140 TAEGSAGRVE 1150 NFGKRKPLLQ 1160 AWVSPSETHP 1170 VSAQPGAGTG 1180 SAKHRLHPVK 1190 PMNAMATKVA 1200 NCSLGTATII 1210 SENLNNEVMM 1220 KKYSPSDPAF 1230 AYAQLTHDEL 1240 IQLVLKQKET 1250 ISKKEFQVRE 1260 LEDYIDNLLV 1270 RVMEETPNIL 1280 RIPTQVGKKA GKM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030670 phagocytic vesicle membrane
Cellular Component GO:0055037 recycling endosome
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0070164 negative regulation of adiponectin secretion
Biological Process GO:0015031 protein transport
Biological Process GO:0045055 regulated exocytosis

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.