Search Results
Overview
| Uniprot ID | Q6X4W1 |
|---|---|
| Protein Name | NMDA receptor synaptonuclear signaling and neuronal migration factor |
| Gene Name | NSMF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 522 | WKSRQHSKLLDFDDV |
Function
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells
Protein Sequence
10
MGAAASRRRA
20
LRSEAMSSVA
30
AKVRAARAFG
40
EYLSQSHPEN
50
RNGADHLLAD
60
AYSGHDGSPE
70
MQPAPQNKRR
80
LSLVSNGCYE
90
GSLSEEPSIR
100
KPAGEGPQPR
110
VYTISGEPAL
120
LPSPEAEAIE
130
LAVVKGRRQR
140
HPHHHSQPLR
150
ASPGGSREDV
160
SRPCQSWAGS
170
RQGSKECPGC
180
AQLAPGPTPR
190
AFGLDQPPLP
200
ETSGRRKKLE
210
RMYSVDRVSD
220
DIPIRTWFPK
230
ENLFSFQTAT
240
TTMQAISVFR
250
GYAERKRRKR
260
ENDSASVIQR
270
NFRKHLRMVG
280
SRRVKAQTFA
290
ERRERSFSRS
300
WSDPTPMKAD
310
TSHDSRDSSD
320
LQSSHCTLDE
330
AFEDLDWDTE
340
KGLEAVACDT
350
EGFVPPKVML
360
ISSKVPKAEY
370
IPTIIRRDDP
380
SIIPILYDHE
390
HATFEDILEE
400
IERKLNVYHK
410
GAKIWKMLIF
420
CQGGPGHLYL
430
LKNKVATFAK
440
VEKEEDMIHF
450
WKRLSRLMSK
460
VNPEPNVIHI
470
MGCYILGNPN
480
GEKLFQNLRT
490
LMTPYRVTFE
500
SPLELSAQGK
510
QMIETYFDFR
520
LYRLWKSRQH
530
SKLLDFDDVL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097440 | apical dendrite |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Biological Process | GO:0071230 | cellular response to amino acid stimulus |
| Biological Process | GO:0071257 | cellular response to electrical stimulus |
| Biological Process | GO:0071371 | cellular response to gonadotropin stimulus |
| Biological Process | GO:2001224 | positive regulation of neuron migration |
| Biological Process | GO:0048814 | regulation of dendrite morphogenesis |
| Biological Process | GO:0043523 | regulation of neuron apoptotic process |
| Biological Process | GO:0048168 | regulation of neuronal synaptic plasticity |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.