Search Results
Overview
| Uniprot ID | Q6XQN6 |
|---|---|
| Protein Name | Nicotinate phosphoribosyltransferase |
| Gene Name | NAPRT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | RLIAGPEKRLLEMGL |
Function
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275)
Protein Sequence
10
MAAEQDPEAR
20
AAARPLLTDL
30
YQATMALGYW
40
RAGRARDAAE
50
FELFFRRCPF
60
GGAFALAAGL
70
RDCVRFLRAF
80
RLRDADVQFL
90
ASVLPPDTDP
100
AFFEHLRALD
110
CSEVTVRALP
120
EGSLAFPGVP
130
LLQVSGPLLV
140
VQLLETPLLC
150
LVSYASLVAT
160
NAARLRLIAG
170
PEKRLLEMGL
180
RRAQGPDGGL
190
TASTYSYLGG
200
FDSSSNVLAG
210
QLRGVPVAGT
220
LAHSFVTSFS
230
GSEVPPDPML
240
APAAGEGPGV
250
DLAAKAQVWL
260
EQVCAHLGLG
270
VQEPHPGERA
280
AFVAYALAFP
290
RAFQGLLDTY
300
SVWRSGLPNF
310
LAVALALGEL
320
GYRAVGVRLD
330
SGDLLQQAQE
340
IRKVFRAAAA
350
QFQVPWLESV
360
LIVVSNNIDE
370
EALARLAQEG
380
SEVNVIGIGT
390
SVVTCPQQPS
400
LGGVYKLVAV
410
GGQPRMKLTE
420
DPEKQTLPGS
430
KAAFRLLGSD
440
GSPLMDMLQL
450
AEEPVPQAGQ
460
ELRVWPPGAQ
470
EPCTVRPAQV
480
EPLLRLCLQQ
490
GQLCEPLPSL
500
AESRALAQLS
510
LSRLSPEHRR
520
LRSPAQYQVV
530
LSERLQALVN
SLCAGQSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| Molecular Function | GO:0016740 | transferase activity |
| Biological Process | GO:0034355 | NAD+ biosynthetic process via the salvage pathway |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.