Search Results

Overview

Uniprot ID	Q6XZF7
Protein Name	Dynamin-binding protein
Gene Name	DNMBP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
594	DIVRGSSKLITEQEL

Function

Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity)

Protein Sequence

10 MEAGSVVRAI 20 FDFCPSVSEE 30 LPLFVGDIIE 40 VLAVVDEFWL 50 LGKKEDVTGQ 60 FPSSFVEIVT 70 IPSLKEGERL 80 FVCICEFTSQ 90 ELDNLPLHRG 100 DLVILDGIPT 110 AGWLQGRSCW 120 GARGFFPSSC 130 VRELCLSSQS 140 RQWHSQSALF 150 QIPEYSMGQA 160 RALMGLSAQL 170 DEELDFREGD 180 VITIIGVPEP 190 GWFEGELEGR 200 RGIFPEGFVE 210 LLGPLRTVDE 220 SVSSGNQDDC 230 IVNGEVDTPV 240 GEEEIGPDED 250 EEEPGTYGVA 260 LYRFQALEPN 270 ELDFEVGDKI 280 RILATLEDGW 290 LEGSLKGRTG 300 IFPYRFVKLC 310 PDTRVEETMA 320 LPQEGSLARI 330 PETSLDCLEN 340 TLGVEEQRHE 350 TSDHEAEEPD 360 CIISEAPTSP 370 LGHLTSEYDT 380 DRNSYQDEDT 390 AGGPPRSPGV 400 EWEMPLATDS 410 PTSDPTEVVN 420 GISSQPQVPF 430 HPNLQKSQYY 440 STVGGSHPHS 450 EQYPDLLPLE 460 ARTRDYASLP 470 PKRMYSQLKT 480 LQKPVLPLYR 490 GSSVSASRVV 500 KPRQSSPQLH 510 NLASYTKKHH 520 TSSVYSISER 530 LEMKPGPQAQ 540 GLVMEAATHS 550 QGDGSTDLDS 560 KLTQQLIEFE 570 KSLAGPGTEP 580 DKILRHFSIM 590 DFNSEKDIVR 600 GSSKLITEQE 610 LPERRKALRP 620 PPPRPCTPVS 630 TSPHLLVDQN 640 LKPAPPLVVR 650 PSRPAPLPPS 660 AQQRTNAVSP 670 KLLSRHRPTC 680 ETLEKEGPGH 690 MGRSLDQTSP 700 CPLVLVRIEE 710 MERDLDMYSR 720 AQEELNLMLE 730 EKQDESSRAE 740 TLEDLKFCES 750 NIESLNMELQ 760 QLREMTLLSS 770 QSSSLVAPSG 780 SVSAENPEQR 790 MLEKRAKVIE 800 ELLQTERDYI 810 RDLEMCIERI 820 MVPMQQAQVP 830 NIDFEGLFGN 840 MQMVIKVSKQ 850 LLAALEISDA 860 VGPVFLGHRD 870 ELEGTYKIYC 880 QNHDEAIALL 890 EIYEKDEKIQ 900 KHLQDSLADL 910 KSLYNEWGCT 920 NYINLGSFLI 930 KPVQRVMRYP 940 LLLMELLNST 950 PESHPDKVPL 960 TNAVLAVKEI 970 NVNINEYKRR 980 KDLVLKYRKG 990 DEDSLMEKIS 1000 KLNIHSIIKK 1010 SNRVSSHLKH 1020 LTGFAPQIKD 1030 EVFEETEKNF 1040 RMQERLIKSF 1050 IRDLSLYLQH 1060 IRESACVKVV 1070 AAVSMWDVCM 1080 ERGHRDLEQF 1090 ERVHRYISDQ 1100 LFTNFKERTE 1110 RLVISPLNQL 1120 LSMFTGPHKL 1130 VQKRFDKLLD 1140 FYNCTERAEK 1150 LKDKKTLEEL 1160 QSARNNYEAL 1170 NAQLLDELPK 1180 FHQYAQGLFT 1190 NCVHGYAEAH 1200 CDFVHQALEQ 1210 LKPLLSLLKV 1220 AGREGNLIAI 1230 FHEEHSRVLQ 1240 QLQVFTFFPE 1250 SLPATKKPFE 1260 RKTIDRQSAR 1270 KPLLGLPSYM 1280 LQSEELRASL 1290 LARYPPEKLF 1300 QAERNFNAAQ 1310 DLDVSLLEGD 1320 LVGVIKKKDP 1330 MGSQNRWLID 1340 NGVTKGFVYS 1350 SFLKPYNPRR 1360 SHSDASVGSH 1370 SSTESEHGSS 1380 SPRFPRQNSG 1390 STLTFNPSSM 1400 AVSFTSGSCQ 1410 KQPQDASPPP 1420 KECDQGTLSA 1430 SLNPSNSESS 1440 PSRCPSDPDS 1450 TSQPRSGDSA 1460 DVARDVKQPT 1470 ATPRSYRNFR 1480 HPEIVGYSVP 1490 GRNGQSQDLV 1500 KGCARTAQAP 1510 EDRSTEPDGS 1520 EAEGNQVYFA 1530 VYTFKARNPN 1540 ELSVSANQKL 1550 KILEFKDVTG 1560 NTEWWLAEVN 1570 GKKGYVPSNY IRKTEYT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005795	Golgi stack
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Biological Process	GO:0060271	cilium assembly
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction

Reference

PMID: N/A