Search Results

Overview

Uniprot IDQ6YHU6
Protein NametRNA (32-2'-O)-methyltransferase regulator THADA
Gene NameTHADA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
575 LQTSIDAKTGQEQSF

Function

Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs

Protein Sequence

10 MGVKKKKEMQ 20 VAALTICHQD 30 LETLKSFADV 40 EGKNLASLLL 50 HCVQLTDGVS 60 QIHYIKQIVP 70 LLEKADKNGM 80 CDPTIQSCLD 90 ILAGIYLSLS 100 LKNPLKKVLA 110 SSLNSLPDFF 120 LPEAMHRFTS 130 RLQEELNTTD 140 LYSYRKVTDN 150 ISSCMENFNL 160 GRASVNNLLK 170 NVLHFLQKSL 180 IEILEENRKC 190 AGNHIIQTQL 200 MNDLLVGIRV 210 SMMLVQKVQD 220 FQGNLWKTSD 230 SPIWQNMCGL 240 LSIFTKVLSD 250 DDLLQTVQST 260 SGLAIILFIK 270 TMFHPSEKIP 280 HLISSVLLRS 290 VDCTSVPEWF 300 MSSCRSLCCG 310 DISQSAVLFL 320 CQGTLAMLDW 330 QNGSMGRSGE 340 ALLLDTAHVL 350 FTLSSQIKEP 360 TLEMFLSRIL 370 ASWTNSAIQV 380 LESSSPSLTD 390 SLNGNSSIVG 400 RLLEYVYTHW 410 EHPLDALRHQ 420 TKIMFKNLLQ 430 MHRLTVEGAD 440 FVPDPFFVEL 450 TESLLRLEWH 460 IKGKYTCLGC 470 LVECIGVEHI 480 LAIDKTIPSQ 490 ILEVMGDQSL 500 VPYASDLLET 510 MFRNHKSHLK 520 SQTAESSWID 530 QWHETWVSPL 540 LFILCEGNLD 550 QKSYVIDYYL 560 PKLLSYSPES 570 LQYMVKILQT 580 SIDAKTGQEQ 590 SFPSLGSCNS 600 RGALGALMAC 610 LRIARAHGHL 620 QSATDTWENL 630 VSDARIKQGL 640 IHQHCQVRID 650 TLGLLCESNR 660 STEIVSMEEM 670 QWIQFFITYN 680 LNSQSPGVRQ 690 QICSLLKKLF 700 CRIQESSQVL 710 YKLEQSKSKR 720 EPENELTKQH 730 PSVSLQQYKN 740 FMSSICNSLF 750 EALFPGSSYS 760 TRFSALTILG 770 SIAEVFHVPE 780 GRIYTVYQLS 790 HDIDVGRFQT 800 LMECFTSTFE 810 DVKILAFDLL 820 MKLSKTAVHF 830 QDSGKLQGLF 840 QAALELSTST 850 KPYDCVTASY 860 LLNFLIWQDA 870 LPSSLSAYLT 880 QQVACDNGDR 890 PAAVVERNTL 900 MVIKCLMENL 910 EEEVSQAENS 920 LLQAAAAFPM 930 YGRVHCITGA 940 LQKLSLNSLQ 950 LVSEWRPVVE 960 KLLLMSYRLS 970 TVVSPVIQSS 980 SPEGLIPMDT 990 DSESASRLQM 1000 ILNEIQPRDT 1010 NDYFNQAKIL 1020 KEHDSFDMKD 1030 LNASVVNIDT 1040 STEIKGKEVK 1050 TCDVTAQMVL 1060 VCCWRSMKEV 1070 ALLLGMLCQL 1080 LPMQPVPESS 1090 DGLLTVEQVK 1100 EIGDYFKQHL 1110 LQSRHRGAFE 1120 LAYTGFVKLT 1130 EVLNRCPNVS 1140 LQKLPEQWLW 1150 SVLEEIKCSD 1160 PSSKLCATRR 1170 SAGIPFYIQA 1180 LLASEPKKGR 1190 MDLLKITMKE 1200 LISLAGPTDD 1210 IQSTVPQVHA 1220 LNILRALFRD 1230 TRLGENIIPY 1240 VADGAKAAIL 1250 GFTSPVWAVR 1260 NSSTLLFSAL 1270 ITRIFGVKRA 1280 KDEHSKTNRM 1290 TGREFFSRFP 1300 ELYPFLLKQL 1310 ETVANTVDSD 1320 MGEPNRHPSM 1330 FLLLLVLERL 1340 YASPMDGTSS 1350 ALSMGPFVPF 1360 IMRCGHSPVY 1370 HSREMAARAL 1380 VPFVMIDHIP 1390 NTIRTLLSTL 1400 PSCTDQCFRQ 1410 NHIHGTLLQV 1420 FHLLQAYSDS 1430 KHGTNSDFQH 1440 ELTDITVCTK 1450 AKLWLAKRQN 1460 PCLVTRAVYI 1470 DILFLLTCCL 1480 NRSAKDNQPV 1490 LESLGFWEEV 1500 RGIISGSELI 1510 TGFPWAFKVP 1520 GLPQYLQSLT 1530 RLAIAAVWAA 1540 AAKSGERETN 1550 VPISFSQLLE 1560 SAFPEVRSLT 1570 LEALLEKFLA 1580 AASGLGEKGV 1590 PPLLCNMGEK 1600 FLLLAMKENH 1610 PECFCKILKI 1620 LHCMDPGEWL 1630 PQTEHCVHLT 1640 PKEFLIWTMD 1650 IASNERSEIQ 1660 SVALRLASKV 1670 ISHHMQTCVE 1680 NRELIAAELK 1690 QWVQLVILSC 1700 EDHLPTESRL 1710 AVVEVLTSTT 1720 PLFLTNPHPI 1730 LELQDTLALW 1740 KCVLTLLQSE 1750 EQAVRDAATE 1760 TVTTAMSQEN 1770 TCQSTEFAFC 1780 QVDASIALAL 1790 ALAVLCDLLQ 1800 QWDQLAPGLP 1810 ILLGWLLGES 1820 DDLVACVESM 1830 HQVEEDYLFE 1840 KAEVNFWAET 1850 LIFVKYLCKH 1860 LFCLLSKSGW 1870 RPPSPEMLCH 1880 LQRMVSEQCH 1890 LLSQFFRELP 1900 PAAEFVKTVE 1910 FTRLRIQEER 1920 TLACLRLLAF 1930 LEGKEGEDTL 1940 VLSVWDSYAE 1950 SRQLTLPRTE AAC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
Biological Process GO:0030488 tRNA methylation
Biological Process GO:0002128 tRNA nucleoside ribose methylation
Molecular Function GO:0030234 enzyme regulator activity
Biological Process GO:1990845 adaptive thermogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.