Search Results

Overview

Uniprot ID	Q6YN16
Protein Name	Hydroxysteroid dehydrogenase-like protein 2
Gene Name	HSDL2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
284	YPEAVSKKVESTGAV
29	IGKAIALKAAKDGAN
295	TGAVPEFKEEKLQLQ
298	VPEFKEEKLQLQPKP
304	EKLQLQPKPRSGAVE
318	EETFRIVKDSLSDDV
32	AIALKAAKDGANIVI
398	MSGKLKIKGNMALAI
409	ALAIKLEKLMNQMNA
42	ANIVIAAKTAQPHPK
87	QISAAVEKAIKKFGG

Function

Has apparently no steroid dehydrogenase activity (PubMed:19703561). Controls bile acid (BA) and lipid metabolism in response to nutritional cues (PubMed:38820148)

Protein Sequence

10 MLPNTGRLAG 20 CTVFITGASR 30 GIGKAIALKA 40 AKDGANIVIA 50 AKTAQPHPKL 60 LGTIYTAAEE 70 IEAVGGKALP 80 CIVDVRDEQQ 90 ISAAVEKAIK 100 KFGGIDILVN 110 NASAISLTNT 120 LDTPTKRLDL 130 MMNVNTRGTY 140 LASKACIPYL 150 KKSKVAHILN 160 ISPPLNLNPV 170 WFKQHCAYTI 180 AKYGMSMYVL 190 GMAEEFKGEI 200 AVNALWPKTA 210 IHTAAMDMLG 220 GPGIESQCRK 230 VDIIADAAYS 240 IFQKPKSFTG 250 NFVIDENILK 260 EEGIENFDVY 270 AIKPGHPLQP 280 DFFLDEYPEA 290 VSKKVESTGA 300 VPEFKEEKLQ 310 LQPKPRSGAV 320 EETFRIVKDS 330 LSDDVVKATQ 340 AIYLFELSGE 350 DGGTWFLDLK 360 SKGGNVGYGE 370 PSDQADVVMS 380 MTTDDFVKMF 390 SGKLKPTMAF 400 MSGKLKIKGN 410 MALAIKLEKL MNQMNARL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005777	peroxisome
Molecular Function	GO:0016491	oxidoreductase activity
Biological Process	GO:0042632	cholesterol homeostasis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.