Search Results
Overview
| Uniprot ID | Q6ZMR3 |
|---|---|
| Protein Name | L-lactate dehydrogenase A-like 6A |
| Gene Name | LDHAL6A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 155 | WKLSGFPKNRVIGSG |
Function
Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed
Protein Sequence
10
MATIKSELIK
20
NFAEEEAIHH
30
NKISIVGTGS
40
VGVACAISIL
50
LKGLSDELVL
60
VDVDEGKLKG
70
ETMDLQHGSP
80
FMKMPNIVSS
90
KDYLVTANSN
100
LVIITAGARQ
110
KKGETRLDLV
120
QRNVSIFKLM
130
IPNITQYSPH
140
CKLLIVTNPV
150
DILTYVAWKL
160
SGFPKNRVIG
170
SGCNLDSARF
180
RYFIGQRLGI
190
HSESCHGLIL
200
GEHGDSSVPV
210
WSGVNIAGVP
220
LKDLNPDIGT
230
DKDPEQWENV
240
HKKVISSGYE
250
MVKMKGYTSW
260
GISLSVADLT
270
ESILKNLRRV
280
HPVSTLSKGL
290
YGINEDIFLS
300
VPCILGENGI
310
TDLIKVKLTL
320
EEEACLQKSA
330
ETLWEIQKEL
KL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004459 | L-lactate dehydrogenase (NAD+) activity |
| Biological Process | GO:0006089 | lactate metabolic process |
| Biological Process | GO:0042867 | pyruvate catabolic process |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.