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Overview

Uniprot IDQ6ZMT4
Protein NameLysine-specific demethylase 7A
Gene NameKDM7A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
709 VMRNFLQKSQKPSRS

Function

Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853)

Protein Sequence

10 MAGAAAAVAA 20 GAAAGAAAAA 30 VSVAAPGRAS 40 APPPPPPVYC 50 VCRQPYDVNR 60 FMIECDICKD 70 WFHGSCVGVE 80 EHHAVDIDLY 90 HCPNCAVLHG 100 SSLMKKRRNW 110 HRHDYTEIDD 120 GSKPVQAGTR 130 TFIKELRSRV 140 FPSADEIIIK 150 MHGSQLTQRY 160 LEKHGFDVPI 170 MVPKLDDLGL 180 RLPSPTFSVM 190 DVERYVGGDK 200 VIDVIDVARQ 210 ADSKMTLHNY 220 VKYFMNPNRP 230 KVLNVISLEF 240 SDTKMSELVE 250 VPDIAKKLSW 260 VENYWPDDSV 270 FPKPFVQKYC 280 LMGVQDSYTD 290 FHIDFGGTSV 300 WYHVLWGEKI 310 FYLIKPTDEN 320 LARYESWSSS 330 VTQSEVFFGD 340 KVDKCYKCVV 350 KQGHTLFVPT 360 GWIHAVLTSQ 370 DCMAFGGNFL 380 HNLNIGMQLR 390 CYEMEKRLKT 400 PDLFKFPFFE 410 AICWFVAKNL 420 LETLKELRED 430 GFQPQTYLVQ 440 GVKALHTALK 450 LWMKKELVSE 460 HAFEIPDNVR 470 PGHLIKELSK 480 VIRAIEEENG 490 KPVKSQGIPI 500 VCPVSRSSNE 510 ATSPYHSRRK 520 MRKLRDHNVR 530 TPSNLDILEL 540 HTREVLKRLE 550 MCPWEEDILS 560 SKLNGKFNKH 570 LQPSSTVPEW 580 RAKDNDLRLL 590 LTNGRIIKDE 600 RQPFADQSLY 610 TADSENEEDK 620 RRTKKAKMKI 630 EESSGVEGVE 640 HEESQKPLNG 650 FFTRVKSELR 660 SRSSGYSDIS 670 ESEDSGPECT 680 ALKSIFTTEE 690 SESSGDEKKQ 700 EITSNFKEES 710 NVMRNFLQKS 720 QKPSRSEIPI 730 KRECPTSTST 740 EEEAIQGMLS 750 MAGLHYSTCL 760 QRQIQSTDCS 770 GERNSLQDPS 780 SCHGSNHEVR 790 QLYRYDKPVE 800 CGYHVKTEDP 810 DLRTSSWIKQ 820 FDTSRFHPQD 830 LSRSQKCIRK 840 EGSSEISQRV 850 QSRNYVDSSG 860 SSLQNGKYMQ 870 NSNLTSGACQ 880 ISNGSLSPER 890 PVGETSFSVP 900 LHPTKRPASN 910 PPPISNQATK 920 GKRPKKGMAT 930 AKQRLGKILK 940 LNRNGHARFF V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016706 2-oxoglutarate-dependent dioxygenase activity
Molecular Function GO:0032452 histone demethylase activity
Molecular Function GO:0071558 histone H3K27me2/H3K27me3 demethylase activity
Molecular Function GO:0051864 histone H3K36 demethylase activity
Molecular Function GO:0032454 histone H3K9 demethylase activity
Molecular Function GO:0140683 histone H3K9me/H3K9me2 demethylase activity
Molecular Function GO:0035575 histone H4K20 demethylase activity
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030901 midbrain development
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

PMID: N/A